background and aims: the aim of this study was to determine the correlation between the hepatitis b virus surface ag (hbsag) genotypes and variations in the clinical/serological pictures among hbsag positive chronic patients from south khorasan province of iran. methods: twenty-five patients were enrolled in this study. the hbs ag gene was amplified and was directly sequenced. genotypes and nuc...

    Abstract   Background: Hepatitis B virus infection is an important cause of liver morbidity and   mortality worldwide. HDV changes the natural course of HBV. The prevalence of HDV infection wasn’t determined in the various groups of HBV infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and HCC) in Iran. We aimed to research the prevalence of hepatitis D virus infection in v...

Cytogenetic analysis of metaphase chromosome spreads from peripheral blood cells of hepatitis B virus (HBV) chronic carriers and HBV-negative individuals of the same ethnic origin revealed a significantly higher incidence of chromosome breaks and other mitotic aberrations in the HBV chronic carriers. The highest incidence of chromosome breaks was found in chronic carriers who evidenced circulat...

background: it is estimated that about 370 million people are chronic carriers of hbv worldwide. apparently 3% of iranian populations are chronic carriers of this virus. we aimed to evaluate the viral dna in biological fluids of chronic hepatitis patients compared to a control group. methods: the current case-control study was designed to evaluate the viral dna in biological fluids of 70 chroni...

abstract   background: hepatitis b virus infection is an important cause of liver morbidity and mortality worldwide. hdv changes the natural course of hbv. the prevalence of hdv infection wasn’t determined in the various groups of hbv infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and hcc) in iran. we aimed to research the prevalence of hepatitis d virus infection in various...

OBJECTIVE The aim of this study was to determine tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) release in response to platelet-activating factor (PAF) induction in peripheral blood mononuclear cells (PBMCs) from chronic hepatitis B virus (HBV) carriers. METHODS Subjects were grouped into three subgroups. The mean age was 37 +/- 10 years. Group A (n = 15), group B (n = 10) a...

Background: The household transmission of hepatitis B virus (HBV) is a major health problem. High incidence of HBV infection is observed within the household contacts of HBV carriers. We aimed to evaluate serological markers of hepatitis B infection among family members of HBV carriers in Arak, central Iran. Methods<stron...

objectives this study evaluates the correlation between hbv infection and snp in il-10 gene promoter. patients and methods ninety-six hbv-infected patients (32 chronic hepatitis b infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. three biallelic (-819,-592,-1082) regions in the il-10 gene promoter were sequenced for all patients. r...

The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg(+)) group (P < 0.001). Spec...