نتایج جستجو برای: hbsag epitopes mutations
تعداد نتایج: 201746 فیلتر نتایج به سال:
abstract background: naturally occurred hepatitis b virus (hbv) with surface mutations in a variety of chronic hepatitis b (chb) patients who have received no vaccine or hbig bearing substitutions in surface protein, have been reported. objectives: current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among iranian carriers is limited. patients and m...
conclusions the distribution of amino acid mutations as well as the ratio between missense and silent nucleotide mutations (dn/ds) showed that a narrowly focused immune pressure had already been on the surface protein (especially ctl epitopes) which led to the emergence of escape mutants in these patients who were in tolerance phase of chronicity. materials and methods the surface genes from 17...
Objective (s):The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. Materials and Methods: 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples...
Abstract Background: Naturally occurred hepatitis B virus (HBV) with surface mutations in a variety of chronic hepatitis B (CHB) patients who have received no vaccine or HBIG bearing substitutions in surface protein, have been reported. Objectives: Current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among Iranian carriers is limited. Patients and M...
objective (s):the aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis b surface antigen (hbsag)-positive chronic hepatitis b virus (hbv) patients. materials and methods: 16 patients received the hbv vaccine and another 16 individuals from the control group did not. the surface gene was amplified and directly sequenced from samples ...
Mutations within the coding region of hepatitis B surface antigen (HBsAg) have been found naturally in chronic carriers. To characterize the mutations of HBsAg from Iranian chronic carriers who were vaccine and/or medication naive. The surface genes from 360 patients were amplified and directly sequenced. The distribution of amino acid substitutions was classified according to different immune ...
background co-infection with human immunodeficiency virus (hiv) and hepatitis b virus (hbv) is common due to shared routes of transmission, as reported approximately 10% of 33 million hiv-infected patients worldwide are chronically infected with hbv. mutations of hbsag especially within the “a” determinant could alter the antigenicity of the protein, causing failure of hbsag neutralization and ...
conclusions these data will be beneficial for designing more advanced antibodies for the recognition of the hbsag in diagnostics. in addition, the results of this study may assist in the design or development of more effective hepatitis b vaccines. results the g145r mutation causes a considerable reduction in the immunogenic activity of the hbsag through a conformational change in the hbsag ant...
OBJECTIVE S The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. MATERIALS AND METHODS 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples p...
Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino a...
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