نتایج جستجو برای: hbsag epitopes mutations

تعداد نتایج: 201746  

Journal: :iranian journal of virology 0
hossein keyvani department of virology, iran university of medical sciences, tehran, iran fatemeh ramezani hepatitis b molecular laboratory-department of virology-school of public health-tehran university of medical sciences, tehran, iran seyem mohamad jazayeri hepatitis b molecular laboratory-department of virology-school of public health-tehran university of medical sciences, tehran, iran seyed hamid reza monavari department of virology, iran university of medical sciences, tehran, iran farah bokharaei-salim department of virology, iran university of medical sciences, tehran, iran seyed moayed alavian middle east liver diseases center (meld centers) tehran, iran

abstract background: naturally occurred hepatitis b virus (hbv) with surface mutations in a variety of chronic hepatitis b (chb) patients who have received no vaccine or hbig bearing substitutions in surface protein, have been reported. objectives: current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among iranian carriers is limited. patients and m...

Journal: :jundishapur journal of microbiology 0
sajad shahmoradi hepatitis b molecular laboratory, department of virology-school of public health, tehran university of medical sciences, tehran, ir iran mohammad hossein somi liver and gastrointestinal disease research center, eastern azarbyjan university of medical sciences, tabriz, ir iran mehdi norouzi hepatitis b molecular laboratory, department of virology-school of public health, tehran university of medical sciences, tehran, ir iran seyed moayed alavian baqiyatallah university of medical sciences, baqiyatallah research center for gastroenterology and liver disease, tehran, ir iran hadi karimzadeh hepatitis b molecular laboratory, department of virology-school of public health, tehran university of medical sciences, tehran, ir iran ramin rahimnia hepatitis b molecular laboratory, department of virology-school of public health, tehran university of medical sciences, tehran, ir iran

conclusions the distribution of amino acid mutations as well as the ratio between missense and silent nucleotide mutations (dn/ds) showed that a narrowly focused immune pressure had already been on the surface protein (especially ctl epitopes) which led to the emergence of escape mutants in these patients who were in tolerance phase of chronicity. materials and methods the surface genes from 17...

Objective (s):The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. Materials and Methods: 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples...

Abstract Background: Naturally occurred hepatitis B virus (HBV) with surface mutations in a variety of chronic hepatitis B (CHB) patients who have received no vaccine or HBIG bearing substitutions in surface protein, have been reported. Objectives: Current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among Iranian carriers is limited. Patients and M...

Journal: :iranian journal of basic medical sciences 0
maryam daram hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran ghodratollah montazeri digestive disease research center, shariati hospital, tehran, iran hadi karimzadeh hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran reza malekzadeh digestive disease research center, shariati hospital, tehran, iran mahmood mahmoodi department of epidemiology, school of public health, tehran university of medical sciences, tehran, iran zahra goodarzi hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran

objective (s):the aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis b surface antigen (hbsag)-positive chronic hepatitis b virus (hbv) patients. materials and methods: 16 patients received the hbv vaccine and another 16 individuals from the control group did not. the surface gene was amplified and directly sequenced from samples ...

Journal: :Journal of viral hepatitis 2013
A Khedive M Norouzi F Ramezani H Karimzadeh S M Alavian R Malekzadeh G Montazeri A Nejatizadeh M Ziaee F Abedi B Ataei M Yaran B Sayad M H Somi G Sarizadeh I Sanei-Moghaddam F Mansour-Ghanaei H Rafatpanah M A Pourhosseingholi H Keyvani E Kalantari M Saberifiroozi M A Judaki S Ghamari M Daram M Mahabadi Z Fazeli Z Goodarzi V Poortahmasebi S M Jazayeri

Mutations within the coding region of hepatitis B surface antigen (HBsAg) have been found naturally in chronic carriers. To characterize the mutations of HBsAg from Iranian chronic carriers who were vaccine and/or medication naive. The surface genes from 360 patients were amplified and directly sequenced. The distribution of amino acid substitutions was classified according to different immune ...

Journal: :jundishapur journal of microbiology 0
chiman karami department of virology, ahvaz jundishapur university of medical sciences, ahvaz, iran ahmad h adli department of virology, golestan university of medical sciences, gorgan, iran sareh zhand department of biotechology, golestan university of medical sciences, gorgan, iran alijan tabarraei department of microbiology, golestan university of medical sciences, gorgan, iran reza talei department of microbiology, lorestan university of medical sciences, khorramabad, iran mohsen saeidi stem cell research center, golestan university of medical sciences, gorgan, iran

background co-infection with human immunodeficiency virus (hiv) and hepatitis b virus (hbv) is common due to shared routes of transmission, as reported approximately 10% of 33 million hiv-infected patients worldwide are chronically infected with hbv. mutations of hbsag especially within the “a” determinant could alter the antigenicity of the protein, causing failure of hbsag neutralization and ...

Journal: :hepatitis monthly 0
reza rezaee ministry of health and medical education, deputy of curative affairs, budget administration, tehran, ir iran mansour poorebrahim department of medical biotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, ir iran saeideh najafi department of microbiology, tonekabon branch, islamic azad university, tonekabon, mazandaran, ir iran solmaz sadeghi department of medical biotechnology, school of advanced technologies in medicine, tehran university of medical sciences, tehran, ir iran alieh pourdast department of infectious diseases, imam khomeini hospital complex, tehran university of medical sciences, tehran, ir iran seyed moayed alavian middle east liver diseases (meld) center, tehran, ir iran; baqiyatallah research center for gastroenterology and liver diseases, baqiyatallah university of medical sciences, tehran, ir iran

conclusions these data will be beneficial for designing more advanced antibodies for the recognition of the hbsag in diagnostics. in addition, the results of this study may assist in the design or development of more effective hepatitis b vaccines. results the g145r mutation causes a considerable reduction in the immunogenic activity of the hbsag through a conformational change in the hbsag ant...

2014
Maryam Daram Ghodratollah Montazeri Hadi Karimzadeh Reza Malekzadeh Mahmood Mahmoodi Zahra Goodarzi Hossein Keyvani Shahram Mirmomen Seyed Moayed Alavian Michael Roggendorf Seyed Mohammad Jazayeri

OBJECTIVE S The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. MATERIALS AND METHODS 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples p...

Abolfazl Khedive Alireza Namazi Behrooz Ataei Majid Yaran Mehdi Norouzi, Mohammad Ali Judaki Ramin Rahimnia Reza Malekzadeh, Seyed Ali Ghorashi Seyed Moayyed Alavian Seyed Mohammad Jazayeri, Shiva Ghamari

Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino a...

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