Erythrocytes were fractionated, by centrifugation, on the basis of cell density, which is proportional to cell age. Glycated hemoglobin (Hb A1c) in the fractionated cells was measured and compared with the Hb A1c in whole blood and with the fructosamine concentrations in plasma of normal and diabetic subjects. In normal subjects, Hb A1c increased according to the age of the erythrocytes, but hy...

Hemoglobin A1c (Hb A1c) 1 is a mainstay of diabetes diagnosis and management that allows clinicians to estimate the recent mean blood glucose concentration of a patient. Glycation of hemoglobin is an irreversible, nonenzymatic process that depends on the glucose concentration in red blood cells (RBCs), and Hb A1c represents the integrated glucose concentration in RBCs over their life span. RBC ...

background: for decades, it was suspected that diabetes contributed to poorer oral health and the increased frequency of periodontitis. more recently it was found that periodontitis could adversely affect glycemic control in diabetics. the aim of this study was to compare periodontal parameters with the metabolic sugar levels of diabetic and non-diabetic individuals. materials and methods: in t...

BACKGROUND Many countries have implemented, or are considering, a change in hemoglobin A1c (Hb A1c) units from traditional percentage values [Diabetes Control and Complications Trial (DCCT)] to the new Système International d'Unités (SI) unit in millimoles per mole. Concern exists that such a large alteration in numeric values might lead, through confusion, to a deterioration in patients' glyce...

A 52-year-old woman with a medical history of hepatitis B, hyperlipidemia, hypertension, anemia, and depression presented to the internal medicine clinic for a routine visit. Laboratory tests 3 months previously had revealed an impaired fasting glucose concentration of 5.9 mmol/L (106 mg/dL) [reference interval, 3.9 –5.6 mmol/L (70 –100 mg/dL)]. Therefore, a hemoglobin (Hb) A1c analysis was per...

Hemoglobin A1c (Hb A1c) 2 is the analyte most commonly measured in clinical laboratories for patients with diabetes mellitus. Physicians use Hb A1c to monitor long-term glycemic control, adjust therapy, and predict complications of diabetes. Recently, Hb A1c was added as a criterion for the diagnosis of diabetes. Unlike most analytes, many patients with diabetes know their Hb A1c value and are ...

introduction: glycemia and blood glucose levels are under the effect of hb a1c and therefore they could be considered as a valid index for the follow-up and control of diabetes .there are different and controversial reports on the effects of iron deficiency anemia on hb a1c. effects of ida in non diabetic patients are also unknown. the aim of the study was the comparison of hb a1c levels in hea...

Hemoglobin A1c, the most abundant minor hemoglobin component in human erythrocytes, is formed by the condensation of glucose with the N-terminal amino groups of the beta-chains of Hb A. The biosynthesis of this glycosylated hemoglobin was studied in vitro by incubating suspensions of reticulocytes and bone marrow cells with [3H]leucine or 59Fe-bound transferrin. In all experiments, the specific...