Serum haptoglobin levels have been studied in patients with a number of haemolytic disorders. In general, serum haptoglobins were low in patients with increased haemolysis. Values were reduced irrespective of whether haemolysis occurred intravascularly or extravascularly. The reduction was related to the amount of haemoglobin destroyed per day. Serum haptoglobins may be raised in certain neopla...

LECTROPHORETIC variants of serum proteins which bind hemoglobin E have been referred to in man (SMITHIES and WALKER 1956) and swine (KRISTJANSSON 1961) as haptoglobins. IMLAH (1964) found that these same electrophoretic variants of swine could be demonstrated only if old homoglobin or alkaline hematin rather than fresh hemoglobin was added to swine sera prior to electrophoresis. Consequently IM...

A B S T R A C T Using a radioimmunoassay method in conjunction with double diffusion studies, we characterized the antigenic determinants of the three Hp Bellevue phenotypes. An antigenic model based on these data indicates that each phenotype comprises a heterogeneous group of proteins with properties depending on their content of normal (hp,8) and of mutant (hp,8Bellevue) chains of haptoglobi...