Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-arene and anion-arene binding. It is not immediately clear why electrostatic Hammett parameters shou...

The relative rates of the Rh(II)-mediated carbenoid insertion into the benzylic C-H bonds of a series of para-substituted phenyl substrates have been measured by an indirect intramolecular competition method. Three catalysts, rhodium(II) acetate, rhodium(II) trifluoroacetate, and rhodium(II) acetamide, were investigated. The effect of solvent was also studied on the reactions with rhodium(II) a...

1 In conjunction with his Motion to Intervene, Defendant-Intervenor Seth Hammett (“Defendant-Intervenor Hammett”) attached an Answer, Motion to Dismiss and Brief in Support. (Doc. 80). After the Court permitted Defendant-Intervenor Hammett’s intervention as an individual defendant, he re-filed his Answer, Motion to Dismiss and Supporting Brief, (Docs. 120, 121 and 122), which are now pending be...

Arylboronic acids were found to be strong competitive inhibitors of subtilisin and chymotrypsin. The binding constants are strongly pH dependent and give a Hammett-type plot with a slope of -0.885. The pH dependence, the Hammett plot, and nmr model-system studies indicate that inhibition is due to electron-pair donation by the active site histidine to the bound inhibitor.

An initial rate evaluation of the triazolium-catalysed benzoin condensation permitted a Hammett structure–activity analysis providing insight into rate-limiting step.

A computational Hammett analysis of oxy-insertion into platinum-aryl bonds is performed. Modeled transformations involve the two-step conversion of [((X)bpy)Pt(R)(OY)](+) (R = p- or m-X-C(6)H(4); Y = 4- or 3-X-pyridine; (X)bpy = 4,4'- or 5,5'-X-bpy; X = NO(2), H, OMe, NMe(2)) proceeding through a Pt-oxo intermediate to form aryloxide [((X)bpy)Pt(OR)(Y)](+), which contrasts a one-step non-redox ...