Lariam (pharmacological name mefloquine) is an antimalaria drug discovered by the US Army shortly after the Vietnam War, and subsequently marketed worldwide by F. Hoffmann-La Roche. The first reported trials of mefloquine were in prisoners, and were performed at the Joliet Correctional Center, Illinois, in 1975, and at the Maryland House of Correction in 1976.1,2 Halfan (pharmacological name ha...

Halofantrine hydrochloride (halfan) was administered via oral route to matured female wistar rats weighing 180-200 g. The Wistar rats were randomly selected and divided into six groups of four rats each, making a total of twenty four rats and coded A1, A2, A3, B1, B2 and B3. Groups A3 and B3 were used as controls. Three consecutive doses of 1 mg/100 g halfan each were administered to group A1 a...

The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. Group A (control group) was given only clean water. Groups B. C. D and E received 0.7; 1.4; 2.1 and 2. 8g/kg Body not of halofantrine hydrochloride administered orally every six hours for three times (comple...

Background: Malaria remains the world’s most devastating human parasitic infection. Our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (Fansidar, Halfan, Quinine, Coartem and Chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (Hb AA, Hb AS and Hb SS). Materials and Methods: Spectrophotometric method was ...

Methods Haemozoin was extracted from blood samples of all the malaria positive patients studied by centrifugation, and the concentration was analyzed spectrophotometrically at 400nm wavelength. Comparative anti-malaria activity of some conventional antimalarials, including Maldox, Halfan, Artecxin, Amatem, Mefloquine (quinolines) and Malmed, as well as the leaf and stem back extracts of some lo...

background: malaria remains the world’s most devastating human parasitic infection. our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (fansidartm, halfantm, quinine, coartemtm and chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (hb aa, hb as and hb ss). materials and methods: spectrophotometric metho...