objective :t o investigate the hematologic indices of mothers in non-immune hydrops fetalis pregnancies and identify the possible causative role of alpha-thalassemia among them. material and methods: from 2005 to 2007, 11386 hydrops fetalis cases in three major obstetric hospitals affiliated to tehran university of medical sciences were recorded. indirect coombs test and hematologic indices of ...

HemoglobinE (HbE), havin| the substitutionof glutamic acidwithlysineat the 26thamino acidresidue onp-globin, is the most common mutaion of the p-globin gei" in South East Asia. A compound heteroqgote of this mutation with another mutation in the $-globin gene Iead.s to o'rrrr)r"h"^otyi, disease known as hemoglobin Et\-thalnssemia d.isease, where repeated blood transfusions are neededIn an Ind.o...

background : using two logistic regression models, we determined the associates of poor physical and mental health related quality of life (hrqol) among beta thalassemia patients. methods : in this cross-sectional study which was conducted during 2006 and 2007 in outpatient adult thalassemia clinic, blood transfusion organization, tehran, iran, short form 36 (sf-36) was used for measuring hrqol...

By URSULA MULLER-EBERHARD, MARION E. ERLAXDSON, H. EARL GINN AND CARL H. SMITH T HALASSEMIA MAJOR is one of the conditions in which severe secondary hemochromatosis occurs as a principal complication. This type of hemochromatosis is manifest at an earlier age than is primary hemochromatosis. In addition to parenteral administration of iron in the form of frequent blood transfusions, increased i...

T halassemia syndromes are the most prevalent autosomal recessive single gene disorders in Iran.1,2 Interactions of different types of hemoglobinopathies can lead to thalassemia syndromes with a variety of phenotypes that range from asymptomatic to severe anemia. The diversity of thalassemia phenotypes depends on the amount of imbalances created between and non-globin chains.3,4 In normal eryth...

Synthesis of globin chains in bone the heterozygotes, there was a signifimarrow and peipheral blood samples cant defect in beta synthesis in the from a black family with mild beta peripheral blood of white subjects, thalassemia was compared with simiwhile in two of three black patients the lar studies in white people. Blood and P/ ratio was in the normal range. Albone marrow were incubated with...