introduction: glabrous skin and hairy skin are innervated by different types of noxious fibers. however, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. methods: in this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into ...

Introduction: Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. Methods: In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into...

Percutaneous absorption of topically applied mannitol and progesterone was compared in vivo with the hairless and hairy rat. Urinary excretion and skin concentration profiles after topical application of mannitol demonstrated that hairless rat skin was a "leakier" barrier to percutaneous absorption of polar compounds than was hairy rat skin, independent of formulation. Liposomal, but not aqueou...

INTRODUCTION Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. METHODS In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into ...

BACKGROUND The efficacy of opioids for neuropathic pain remains controversial. The effects of morphine on pain behavior were investigated in two animal models of neuropathic pain: the spared nerve injury (SNI) model and the spinal nerve ligation (SNL) model. METHODS Nerve injuries were created in rats either by tight ligation and section of the left tibial and common peroneal nerves (SNI) or ...

Reconstruction of the upper lip requires symmetrical reconstruction of hairy male skin according to the aesthetic principle. A moderate defect of the upper lip had nonhairy skin on the upper one-third and hairy skin on the lower two-thirds in a Korean man. A hairy preauricular free flap is useful for correcting superficial-thickness skin defects of the upper lip, when local and regional flaps a...

The scientific literature suggests that barefoot activity may be beneficial. There is a current trend in recreational barefoot activity in children and adults, and barefoot running among athletes. Although the type of skin over most of the body (hairy skin) seems to be easily injured by painful abrading loads, little is known about protection provided by plantar sensory feedback against damage ...

Descending controls of spinal nociceptive processing play a critical role in the development of inflammatory hyperalgesia. Acute peripheral nociceptor sensitization drives spinal sensitization and activates spino-supraspinal-spinal loops leading to descending inhibitory and facilitatory controls of spinal neuronal activity that further modify the extent and degree of the pain state. The afferen...

Vibrotactile thresholds for the glabrous skin of the hand and for the hairy skin of the arm are investigated as a function of frequency in the range from 40 to 2 000 Hz, using a heavy vibrator. These thresholds are expressed as equivalent bone-conduction loss and compared with vibrotactile thresholds determined with bone vibrators on the arm and mastoid for normally hearing and severely hearing...

We investigated the tactile perception of a liquid surface that can be clearly felt as a thin line by a hand moving in the liquid. Although this phenomenon was first reported by Meissner in 1859 and is quite well known, the underlying mechanism is poorly understood. This study aimed to clarify how we perceive the boundary between the atmosphere and water as a cutaneous sensation. We found that ...