dear editor-in-chief a 28 yr male was presented in october 2015 at medicine outpatient department, safdarjung hospital, new delhi- india with generalized weakness, fever and cough for preceding 15 days. clinicoradiologic examination revealed pallor, firm, non-tender splenomegaly measuring 13.7 cm and hepatomegaly (liver span - 16.9 cm). however, no lymphadenopathy was found.

Literature review shows that hepatitis C infection may increase the risk of non-hodgkin lymphoma. Reactivation of hepatitis B infection has been reported in patients with hairy cell leukemia after chemotherapy and/or splenectomy. We present hepatitis B surface (HBs) antigenemia and concurrent hepatitis C virus (HCV) seropositivity in a case of hairy cell leukemia. Key Words: Hairy cell leukemi...

literature review shows that hepatitis c infection may increase the risk of non-hodgkin lymphoma. reactivation of hepatitis b infection has been reported in patients with hairy cell leukemia after chemotherapy and/or splenectomy. we present hepatitis b surface (hbs) antigenemia and concurrent hepatitis c virus (hcv) seropositivity in a case of hairy cell leukemia. key words: hairy cell leukemia...

patients with lymphoproliferative disorders have cellular immune deficiency and are susceptible to typical and atypical mycobacterial infections.hairy cell leukemia is a b-cell type lymphoproliferative disorder.2-cda is the choice of treatment for patients with hairy cell leukemia. it is a synthetic antineoplastic agent with immunosuppressive effects.we present development of pulmonary and meni...

introduction: hcl is a rare malignant condition that is curable if diagnosed early. hcl can present with reduced blood cells and splenomegaly which maybe misdiagnosed with other conditions. the aim of the present study was to determine the frequency of early clinical and laboratory findings as well as the response rate of patients to the standard treatment regimen of cladribine. methods: the st...

The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials in melanoma patients. However, the MEK-ERK pathway status in hairy cell leukemia has not been thoroughly investiga...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

Most cases of hairy cell leukemia represent malignancies of B cells. However, recent findings suggest that there is a spectrum of functional capacities within the entity hairy cell leukemia. Two patients with hairy cell leukemia, whose malignant cells in the peripheral blood showed both T- and B-cell features, are reported. The malignant cells of the spleens showed only B-cell characteristics. ...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

Dear Editor-in-Chief A 28 yr male was presented in October 2015 at Medicine Outpatient Department, Safdarjung Hospital, New Delhi- India with generalized weakness, fever and cough for preceding 15 days. Clinicoradiologic examination revealed pallor, firm, non-tender splenomegaly measuring 13.7 cm and hepatomegaly (liver span - 16.9 cm). However, no lymphadenopathy was found.