Extramedullary haematopoiesis is the production of blood elements outside the bone marrow cavity. In our case computed tomography and magnetic resonance imaging revealed the presence of a rare localization of extramedullary haematopoiesis with encasement of the biliary system in a 59 years-old male Caucasian patient, with chronic myelofibrosis and hepatic failure's symptomatology. Computed tomo...

The Wilms’ tumour gene (Wt1) was originally identified as a gene involved in predisposition to the childhood kidney cancer Wilms tumour. Wt1 conventional KOs are embryonic lethal. The mutant embryos die before E13.5 days due to cardiac defects and spleen, kidney, and gonads fail to form. The role of Wt1 in haematopoiesis is controversial. Some evidence suggests that Wt1 is required for embryoni...

Intrathoracic extramedullary haematopoiesis is a rare entity encountered in patients with long standing anaemias such as thalassaemia and congenital spherocytosis. It is rare in patients with homozygous sickle cell disease; only 11 cases of intrathoracic and two cases of pelvic extramedullary haematopoiesis have been documented in the literature. We report the case of a 30-year old man with hom...

The Wilms’ tumour gene (Wt1) was originally identified as a gene involved in predisposition to the childhood kidney cancer Wilms tumour. Wt1 conventional KOs are embryonic lethal. The mutant embryos die before E13.5 days due to cardiac defects and spleen, kidney, and gonads fail to form. The role of Wt1 in haematopoiesis is controversial. Some evidence suggests that Wt1 is required for embryoni...

The Wilms’ tumour gene (Wt1) was originally identified as a gene involved in predisposition to the childhood kidney cancer Wilms tumour. Wt1 conventional KOs are embryonic lethal. The mutant embryos die before E13.5 days due to cardiac defects and spleen, kidney, and gonads fail to form. The role of Wt1 in haematopoiesis is controversial. Some evidence suggests that Wt1 is required for embryoni...

MicroRNA-145 (miR-145) is considered to play key role in many cellular processes, such as proliferation, differentiation and apoptosis by inhibiting target gene expression. The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression. We are beginning to understand the functions of miRNA-145 played during essential biological processes ...

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Folia Biologica > Archive 2021, Vol. 67 Issue 4 Latent Defect in Haematopoiesis of… Fol. Biol. 67, 135-135 https://doi.org/10.14712/fb2021067040135 of UBC-GFP Mice Sheds Light on the Lymphoid Developmental Potential Haematopoietic Stem Cells Emanuel Nečas, K. Faltusová, C-L. Chen Institute Pathological Physiology, First Faculty Medicine, Charles University, Czech Republic Received November 2021...

Anthrax receptor (ATR) shares similarities with molecules relevant to haematopoiesis. This suggests that anthrax proteins might bind to these mimicking molecules and exert non-specific haematopoietic effects. The haematopoietic system is the site of immune cell development in the adult. As such, ATR ligand, protective antigen (PA) and the other anthrax proteins, lethal factor, edema factor, cou...