Three monoclonal antibodies--H59, H71, and H72--which react with human breast cancers have been developed using the estrogen-dependent human breast cancer cell line, ZR-75-1, as the immunogen. H59 bound only to estrogen receptor-positive, estrogen-regulated breast cancer cells in culture, whereas H71 and H72 bound breast cancer cells irrespective of the estrogen receptor content. All three anti...

Monoclonal antibodies which bind to breast cancer have been used to evaluate the detection of metastatic disease in axillary lymph nodes. Three monoclonal antibodies (H59, H71, and H72) were reacted with tissue sections of primary tumors and axillary nodes from 24 mastectomy specimens and four specimens from glandular mastectomies for benign disease. All three antibodies had been shown to react...

High-throughput epidemiological typing systems that provide phylogenetic and genotypic information are beneficial for tracking bacterial pathogens in the field. The incidence of Salmonella enterica serovar Typhi infection in Indonesia is high and is associated with atypical phenotypic traits such as expression of the j and the z66 flagellum antigens. Utilizing a high-throughput genotyping platf...

Allosteric communication among domains in modular proteins consisting of flexibly linked domains with complimentary roles remains poorly understood. To understand how complementary domains communicate, we have studied human Pin1, a representative modular protein with two domains mutually tethered by a flexible linker: a WW domain for substrate recognition and a peptidyl-prolyl isomerase (PPIase...

We study the outcome of an immigration amnesty for a government that faces a trade-off between minimizing the number of unwanted immigrants and expanding the tax base. Since the government is not credible when announcing a generalized amnesty, both the fiscal benefit and the stock of illegal immigrants are sub-optimal. In addition, we argue that amnesties can occur only at irregular intervals a...

The SecY complex associates with the ribosome to form a protein translocation channel in the bacterial plasma membrane. We have used cryo-electron microscopy and quantitative mass spectrometry to show that a nontranslating E. coli ribosome binds to a single SecY complex. The crystal structure of an archaeal SecY complex was then docked into the electron density maps. In the resulting model, two...

out coronary disease. Cathet Cardiovasc Diagn 3: 47, 1977 14. Schnaar RL, Sparks HV: Response of large and small coronary arteries to nitroglycerin, NaNO^, and adenosine. Am J Physiol 22: 223. 1972 15. Harder DR, Belardinelli L, Sperelakis N, Rubio R, Berne RM: Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. Circ Res 44: 176, 19...

trienes, and other derivatives of carbon — 20 Unsaturated Fatty Acids. J Neurochem 38: 1-14, 1982 35. Gingrich RD, Hoak JC: Platelet-endothelial cell interactions. Seminars in Hematology 16: 208-220, 1979 36. Majerus PW, Miletich JP: Relationships between platelets and coagulation factors in hemostasis. Ann Rev Med 29: 41-49, 1978 37. Walsh PN: Platelets and coagulation proteins. Federation Pro...

Bu çalışmada, temsilî bürokrasi kavramının gelişimi ve toplumsal farklılıkların içerisinde temsilinin önemli sonuçlarından birisi olan bürokrasinin meşruiyeti üzerindeki etkisi teorik olarak araştırılmıştır. Temsilî kavramı, bürokrasinin, siyasal iktidarın değişimi ihtimaline karşı mevcut sınıfsal yapısının korunması için icat edilmiş bir kavramdır. Kavram, temel hedefleri sabit kalacak şekilde...