IGF-I and IGF-II are potent mitogens, postulated to exert autocrine/paracrine effects on growth regulation in human lung cancer. Their proliferative effects are modulated by IGF-binding proteins (IGFBPs), which are found in conditioned medium (CM) of lung cancer cell lines. The biological role of the IGFBPs, which are ontogenetically and hormonally regulated, is not fully understood. Both inhib...

The amino acid sequences responsible for H7 and H23 flagellum serology have been identified by using a genetic approach. The H7-specific domain was located between amino acids 352 and 374 of the H7 flagellin. The sequencing data also demonstrated that the difference between the H7 and H23 flagellins in this region results from a single substitution at amino acid 366 (Ser-->Thr). The common epit...

Abstract The practice of kaiy is an ancient medical traditional therapy that still used in Africa and the Middle East. Kaiy Arabic word for cautery; a red-hot iron or coal placed to skin. This causes sharp circular, oval linear burns are symmetrical configuration, usually resulting permanent scars. undertaken by healers. A Somali woman was referred her general practitioner dermatology itchy sca...

We examined the expression levels of the multidrug resistance protein 5 (ABCC5) gene in non-small cell lung cancer (NSCLC) cell lines to clarify the relationship with the sensitivity to gemcitabine. The expression levels of ABCC5 were inversely correlated with gemcitabine sensitivity significantly (r = 0.628; P < 0.01) in 17 NSCLC cells, whereas the expression of ABCC5 in the gemcitabine-resist...

Ganoderma tsugae (GT) is a traditional Chinese medicine that exhibits significant antitumor activities against many types of cancer. This study investigated the molecular mechanism by which GT suppresses the growth of doxorubicin-resistant lung adenocarcinoma H23/0.3 cells. Our results reveal that GT inhibits the viability of H23/0.3 cells in vitro and in vivo and sensitizes the growth suppress...

Pharmacognosy Research,2022,14,3,256-262.DOI:10.5530/pres.14.3.37Published:July 2022Type:Original ArticleAuthors:Abani Kumar Patar, Lakhon Kma, Jitul Barman, Shekhar Ghosh, and Taranga Jyoti Baruah Author(s) affiliations:Abani Baruah* Department of Biochemistry, Assam Royal Global University, Guwahati, Assam, INDIA. Abstract:Background: Naringenin (NGN) is a commonly available flavonoid in the ...

We investigated PD-L1 changes in response to MEK and AKT inhibitors in KRAS mutant lung adenocarcinoma (adeno-NSCLC). PD-L1 expression was quantified using immunofluorescence and co-culture with a jurkat cell-line transfected with NFAT-luciferase was used to study if changes in PD-L1 expression in cancer cell lines were functionally relevant. Five KRAS mutant cell lines with high PD-L1 expressi...

All linear codes of length 100 over a field F which admit the Higman-Sims simple group HS in its rank 3 representation are determined. By group representation theory it is proved that they can all be understood as submodules of the permutation module FΩ where Ω denotes the vertex set of the Higman-Sims graph. This module is semisimple if charF 6= 2, 5 and absolutely indecomposable otherwise. Al...

We describe the production of large amounts of homoand copolymers of polyhydroxyalkanoates (PHAs) by Azotobacter chroococcum strain H23 when growing in culture media amended with alpechin. A. chroococcum grown on NH4+-medium supplemented with alpechin formed PHAs up to 50% of the cell dry weight after 24h. The results show that alpechin supports the growth of strain H23 and also that this waste...

AtT20 (mouse pituitary corticotroph) cells were stably transfected with human proinsulin cDNA. Clone H12 displayed low basal release of insulin-like immunoreactivity (< 1% cell content/30 min) with 17-fold stimulation by isobutylmethylxanthine/forskolin. Clone H23, by contrast, showed higher basal release (2.8% cell content/30 min) and only 6-fold stimulation. To follow the kinetics of conversi...