We demonstrate dramatic breakdown behavior in the current through GaAs/AlGaAs nanoconstrictions (NCs), and find that this exhibits multiple signatures characteristic of the Gunn effect. These include current fluctuations and hysteresis, and electroluminescence that are consistent with the formation of Gunn domains. An analytical model is developed to describe the current–voltage characteristics...

We present and numerically solve a model of the photorefractive Gunn effect. We find that high field domains can be triggered by phase-locked interference fringes, as it has been recently predicted on the basis of linear stability considerations. Since the Gunn effect is intrinsically nonlinear, we find that such considerations give at best order-of-magnitude estimations of the parameters criti...

A theoretical and experimental study of the Gunn effect is presented. It appears that this effect, originally observed by Gunn as a time variation in the current through ohmic samples of n-GaAs when the sample voltage exceeded a critical value, can be accounted for by the transferred electron model of Ridley and Watkins. This model is based on a transfer of electrons from a low-mass, high-mobil...

A general asymptotic analysis of the Gunn effect in n-type GaAs under general boundary conditions for metal-semiconductor contacts is presented. Depending on the parameter values in the boundary condition of the injecting contact, different types of waves mediate the Gunn effect. The periodic current oscillation typical of the Gunn effect may be caused by moving charge-monopole accumulation or ...

ANG II induces vasoconstriction, at least in part, by stimulating NADPH oxidase and generating reactive oxygen species. ANG II also induces heme oxygenase activity, and bilirubin, a product of such activity, possesses antioxidant properties. We hypothesized that bilirubin, because of its antioxidant properties, may reduce the pressor and prooxidant effects of ANG II. Our in vivo studies used th...

Ezetimibe (EZE) selectively blocks intestinal cholesterol absorption by interacting with Niemann-Pick C1 Like 1 (NPC1L1). After administration, EZE is extensively metabolized in liver and intestine to its phenolic glucuronide form (EZE-G) by uridine diphosphate glucuronosyltransferases (UGTs), among which UGT1A1 and 1A3 exhibit highest activity. EZE-G is excreted into bile and undergoes extensi...

Heme oxygenase-1 (HO-1) is induced in the vasculature in the DOCA-salt model of hypertension in rats. Whereas the HO system and its products may exert vasodilator effects, recent studies have suggested that the HO system may predispose to hypertension. The present study examined the effects of selected components of the HO system, specifically, the HO-1 isozyme and the product bilirubin in the ...

Marcus-gunn phenomenon is a congenital and sometimes hereditary anomaly, in which a ptotic eyelid retracts momentarily when the mouth is open, or the jaw is moved. These associated movements attributed to abnormal connections between the central mechanisms innervating the pterygoid and elevator muscles. Sometimes this anomaly is associated with dual,s retraction syndrome, duplex kindneys and ur...