We describe here the first crystalline hydrogen-bonded organic framework made from complementary guanine and cytosine nucleobases.

the hydration of biomolecules is vitally important in molecular biology, so in this paper thesolvation energy and radial distribution function of dna bases have been calculated by themonte carlo simulation.the geometries of isolated adenine, guanine, cytosine, and thyminehave been optimized using 6-31+g(d,p) basis function sets. these geometries then will be used inthe monte carlo calculation o...

X-ray photoelectron spectroscopy was used to analyze commercially available powders of thymine, uracil, cytosine, guanine, adenine, as well DNA isolated from salmon testes and RNA torula yeast. The were pressed onto a sample holder analyzed received the manufacturer. Survey spectra high-resolution O 1s, N C 1s all nucleobases are reported, including small Na contamination in cytosine. Spectra a...

The hydration of biomolecules is vitally important in molecular biology, so in this paper thesolvation energy and radial distribution function of DNA bases have been calculated by theMonte Carlo simulation.The geometries of isolated Adenine, Guanine, Cytosine, and Thyminehave been optimized using 6-31+G(d,p) basis function sets. These geometries then will be used inthe Monte Carlo calculation o...

We performed a theoretical study, at the BLYP/aug-cc-pVDZ level, of mechanisms H-transfer between biologically relevant tautomers cytosine and guanine. The analysis ground- excited state energy barriers conversions showed that in some cases they are lower as compared to ground reactions. inclusion one water molecule catalyst oxo-amino form guanine drastically changes mechanism reactions well st...

the effect of interactions of various ia and iia cations with two positions of the adenine-thymine (a−t) and guanine-cytosine (g−c) base pairs on the geometries and individual hydrogen bond (hb) energies have been investigated by using the atoms in molecules (aim) method at the b3lyp/6-311++g(d,p) level of theory. the cations that possess higher charge/radius (q/rad) ratio make higher changes o...

Although the immobilization of oligonucleotides (nucleic acid) on mineral surfaces is at basis different biotechnological applications, an atomistic understanding interaction nucleic acid components with titanium dioxide has not yet been achieved. Here, adsorption phosphate anion, four DNA bases (adenine, guanine, thymine, and cytosine) some entire nucleotides dinucleotides TiO2 anatase (1 0 1)...

Zebularine (1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one) was studied as both a 2 '-deoxyribosyl 5 '-triphosphate derivative and as a template incorporated into an oligonucleotide. Using a novel pyrosequencing assay, zebularine acted as cytosine analog and was incorporated into DNA with a template pairing profile most similar to cytosine, pairing with greatest efficiency opposite guanine...

Synthetic oligodeoxynucleotides containing unmethylated CpG motifs activate Toll-Like Receptor 9 (TLR9). Our previous studies have shown the role of hydrogen-bond donor and acceptor groups of cytosine and guanine in the CpG motif and identified synthetic immunostimulatory motifs. In the present study to elucidate the significance of N3-position of cytosine and N1-position of guanine in the CpG ...

Synthetic oligodeoxynucleotides containing unmethylated CpG motifs activate Toll-Like Receptor 9 (TLR9). Our previous studies have shown the role of hydrogen-bond donor and acceptor groups of cytosine and guanine in the CpG motif and identified synthetic immunostimulatory motifs. In the present study to elucidate the significance of N3-position of cytosine and N1-position of guanine in the CpG ...