Guanidinoacetic acid, a precursor of creatine, is an essential substrate for muscle energy metabolism. Since guanidinoacetic acid has been reported to be synthesized from arginine and glycine by glycine amidinotransferase (transamidinase) in kidney homogenates or slices, the purpose of this study was to provide evidence of guanidinoacetic acid synthesis in isolated tubules from rat kidneys, and...

Feeding [1-C]-guanidinoacetic acid to shoot primordia, O2 uptake was inhibited and major products were C-glycine, CO2 and C-serine. The direct decarboxylation of [1-C]-guanidinoacetic acid to CO2 and N-methylguanidine, the methylation of [1-C]-guanidinoacetic acid to C-creatine, and the lytic cleavage to urea and C-glycine were all ruled out. Enzymatic transamidinations of [1-C]-guanidinoacetic...

Objective: This study was conducted to evaluate effects of guanidinoacetic acid and creatine supplementation in the presence or absence supplemental choline on body status lean tissue growth.

Effect of vitamin D3 and guanidinoacetic acid on performance, some physiological parameters, carcass characteristics behavior broilers affected by lactic acidosis

The non-specific analytical methods for the guanidinium compounds in biological fluids have been unsatisfactory for many years. The methods presented in this paper have a greatly improved specificity and are not too complex for use in the clinical laboratory. A modified Sakaguchi color reaction for substituted guanidines is used in each procedure. Guanidinoacetic acid is measured by developing ...

Objective: This study was conducted to evaluate the effects of supplemental choline in combination with guanidinoacetic acid or creatine on immune cell function and inflammation growing cattle.

Objective: This study was conducted to evaluate effects of guanidinoacetic acid and creatine supplementation in the presence or absence supplemental betaine on lean tissue growth growing cattle.

It is well established that the last step in the biosynthesis of creatine involves the methylation of guanidinoacetic acid.’ This conclusion is based upon experimental evidence derived from two independent lines of investigation. By application of the isotopic tracer technique, du Vigneaud et al. (2) have demonstrated that the methyl group in creatine is derived from L-methionine; furthermore, ...