This study demonstrates utilization of the novel GTG initiation codon for translation of a human mRNA transcript that encodes the serpin endopin 2B, a protease inhibitor. Molecular cloning revealed the nucleotide sequence of the human endopin 2B cDNA. Its deduced primary sequence shows high homology to bovine endopin 2A that possesses cross-class protease inhibition of elastase and papain. Nota...

Whether or not factors besides hyperphagia influence cellularity of adipose tissue in gold thioglucose (GTG)-treated mice was examined. The animals were treated with GTG (800 mg/kg body weight) or saline as control. Control and one of the GTG-treated groups were given a diet ad libitum and another of the GTG-treated groups was pair-fed to control. In GTG-treated group fed ad libitum, hyperphagi...

To examine the interplay among Gratitude to God (GTG) and daily life experiences affect, we conducted a 14-day diary study in national US sample of 184 adults. GTG minimally fluctuated across days. People who experienced more uplifts had relative both their own baseline others study, while those hassles less baseline. Trait (but not religiousness) buffered these associations. Specifically, trai...

Circulating leptin levels are strongly related to the degree of adiposity, with hyperleptinemia being associated with hyperinsulinemia. In the gold thioglucose-injected mouse (GTG), hyperinsulinemia is an early abnormality in the development of insulin resistance and obesity. In this study, hyperinsulinemia occurred 1 wk post-GTG [GTG, 199 ± 43; age-matched controls (CON), 53 ± 5 μU/ml; P < 0.0...

We demonstrated a germline p53 replication error in two generations of a Li-Fraumeni family affected with liposarcoma, adrenocortical carcinoma, and osteosarcoma. The trinucleotide repeat mutation changed 5'-AGT GTG GTG GTG-3' at codons 215-218 to 5'-AGT TGG TTG GTG GTG-3'. The predicted protein would be elongated by one amino acid (val216-->trp leu) without a change in charge. Detection of p53...

Research relating personality variables to gratitude God (GTG) is in its nascent stages, as only a few descriptive, correlational studies have been conducted on this topic. We investigated whether two kinds of variables—positive emotional traits and adaptive relational styles—predicted higher GTG. Hypotheses linking these GTG were based novel, preregistered conceptual framework. also explored g...

In two pre-registered studies we investigated the cognitive context of gratitude to God (GTG) and fading positive affect grateful memories. Although has been shown causally impact happiness, few have how nature benefactor might experienced gratitude. Participants first recalled a event, human-caused benefit, or God-caused benefit. After recall they reported their current momentary emotions, pas...

1. Over- or undernutrition of newborn mice was caused by suckling in litters consisting initially of four or eighteen pups. After weaning, mice were fed ad lib. At 13 weeks some mice received gold thioglucose (GTG, 600 mg/kg, intraperitoneally) to induce hyperphagia, and all were killed at 39 weeks. 2. Mice suckled in small litters were heavier, with more body fat and protein. GTG treatment ind...

D-chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Effects of gold-thioglucose (GTG) to produce hypothalamic lesions and subsequent obesity are insulin-dependent, suggesting that r...

PCR amplification of repetitive bacterial DNA elements fingerprinting using the (GTG)(5) primer ((GTG)(5)-PCR) was proven to be useful for differentiation of a wide range of lactobacilli (i.e. 26 different (sub)species) at the species, subspecies and potentially up to the strain level. Using this rapid and reproducible genotypic technique, new Lactobacillus isolates recovered from different typ...