background the physiological link between ghrelin and growth hormone (gh) has not yet been fully clarified. furthermore, the existence of a negative feedback mechanism between growth hormone–insulin-like growth factor (gh–igf)-i axis and ghrelin and the influence of amino acids on ghrelin secretion in children remain matters of debate. objectives to understand the regulation of ghrelin secretio...

recombinant human growth hormone (hgh) was given for 6 months or longer to 68 patients with gh deficiency, 6 with turner's syndrome and 5 with achondroplasia, during 1986-1994 in a prospective study. the total weekly administered dose of gh was 0.6 u/kg. by random sampling, 29 of 68 gh deficient patients (42.6%) received twice weekly (2 iw) intramuscular (im) injections, 17 (25%) received ...

background: b-thalassemia major is a serious medical problem. growth retardation is commonly seen in poly-transfused b- thalassemia patients. the exact mechanism of short stature in children with thalassemia major is not well understood, however, it is believed to be multi-factorial. objective: to study the growth state and its relationship to growth hormone (gh) deficiency in b-thalassemia pat...

there are numerous, often contradictory reports on the effect of growth hormone (gh) therapy on thyroid function. these reports prompted us to evaluate the impact of gh therapy on thyroid function in previously euthyroid children with gh deficiency. twenty five clinically and biochemically euthyroid children with gh deficiency were studied. a thyroid profile (t4, free t4, t3 and tsh) was perfor...

INTRODUCTION The incidence of short stature associated with growth hormone deficiency has been estimated to be about 1:4000 to 1:10000. It is the main indication for treatment with recombinant growth hormone. OBJECTIVES The aims of the study were to evaluate the results of growth hormone stimulation tests and identify the growth hormone deficiency predictors. MATERIAL AND METHODS A cross-se...

1. The relationship of lean body mass, plasma insulin concentration and leucocyte active sodium transport with basal metabolic rate was investigated in 24 adults with growth hormone deficiency before and after treatment with recombinant human growth hormone and in 10 patients with untreated acromegaly. 2. Based on total-body potassium determined by whole-body 40K counting, patients with acromeg...