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In this paper, we report analysis of various basaltic lunar samples including 14053 and 14072, KREEP basalt 15386, thirty basalt clasts from Apollo 14 breccia 14321, as well as impact-generated samples (matrix from breccia 14168, olivine vitrophyres 14321,1180 and 14321,1539, and impact melt 14310) using a combination of solution and laser ablation inductively coupled plasma mass spectrometry (...

Background Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, patients hereditary polyneuropathy. Methods This multicentre, open-label extension (OLE) trial enrolled at 43 ho...

We report a new radiometric Rb–Sr age determination of 4.0370.04 Ga for high-Al basaltic clast 14321,1353, which is a Group B Apollo 14 high-Al basalt based on its whole-rock incompatible-traceelement chemistry. In addition, available literature Rb–Sr isotope data for Apollo 14 high-Al basalts were reprocessed using the same decay constant and data reduction protocol as used for sample 14321,13...

Apollo lunar regolith samples are not available in quantity for engineering studies with In-Situ Resource Utilization (ISRU). Therefore, with expectation of a return to the Moon, dozens of regolith (soil) simulants have been developed, to some extent a result of inefficient distribution of NASA-sanctioned simulants. In this paper, we review many of these simulants, with evaluations of their sho...

Mammalian telomeres contain a single-stranded 3' overhang that is thought to mediate telomere protection. Here we identify the TRF2-interacting factor Apollo as a nuclease that contributes to the generation/maintenance of this overhang. The function of mouse Apollo was determined using Cre-mediated gene deletion, complementation with Apollo mutants, and the TRF2-F120A mutant that cannot bind Ap...

Telomeres, the protein-DNA complexes at the ends of linear chromosomes, are protected and regulated by the shelterin molecules, the telomerase complex, and other accessory factors, among which is Apollo, a DNA repair factor of the beta-lactamase/beta-CASP family. Impaired telomere protection in humans causes dyskeratosis congenita and Hoyeraal-Hreidarsson (HH) syndrome, characterized by prematu...