نتایج جستجو برای: groove binding

تعداد نتایج: 424837  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه رازی - دانشکده علوم 1391

we have two part in this thesis, at first: the interaction of native calf thymus dna (ct-dna) with two anthraquinones including quinizarin (1,4- dihydroxy anthraquinone) and danthron (1,8- dihydroxy anthraquinone) in a mixture of 0.04 m brittone-robinson buffer and 50% of ethanol were studied at physiological ph by uv-vis absorption, florescence, circular dichroism spectroscopic methods, viscos...

A. Asadipour A. Foroumadi B. Heidary Alizadeh Gh. Dehghan S. Moghimi V. Derakhsh Ahmadi

The binding interaction of novel podophyllotoxin derivative, (3R,4R)-4-((benzo[d][1,3]dioxol-5-yl)methyl)-dihydro-3-(hydroxy(3,4-dimethoxyphenyl) methyl) furan-2(3H)-one (PPT), with calf thymus DNA (ctDNA) has been examined using UV-Visible absorption spectrophotometry, fluorescence spectroscopy, viscosity measurement and molecular docking studies. UV-Vis absorption results showed hyperchromic ...

Journal: :physical chemistry research 2016
hamid dezhampanah

interactions of cationic tetrakis (n,n´,n´´,n´´´-tetramethyltetra-3,4-pyridinoporphyrazinatocobalt(ii) (co(tmtppa)) with synthetic polynucleotides, poly(a-t), poly(g-c) and calf thymus dna have been characterized in 5 mm phosphate buffer, ph 7.2, by optical absorption and fluorescence spectroscopy. the appearance of hypochromicity effect and the red shift in uv-vis spectrum of porphyrazine was ...

Journal: :علوم دامی ایران 0
هادی آتشی دانش آموخته گروه علوم دامی دانشگاه تهران و استادیار دانشگاه شیراز محمد مرادی شهربابک پردیس کشاورزی و منابع طبیعی دانشگاه تهران حسن مهربانی یگانه عضو هیات علمی گروه علوم دامی، دانشکده¬ی علوم دامی، پردیس کشاورزی و منابع طبیعی دانشگاه تهران سید رضا میرایی آشتیانی پردیس کشاورزی و منابع طبیعی دانشگاه تهران قدرت اله رحیمی میانجی دانشکده¬ی علوم دامی و شیلات، دانشگاه کشاورزی و منابع طبیعی ساری

potential relationships between amino acid motifs in the antigen binding groove of various alleles of the bovine major histocompatibility complex dr (bola-dr) molecule and peripheral blood mononuclear cell (pbmc) proliferation, in response to s. aureus and phytohemaglutinin, were investigated. the animals included in the study were approximately of the same age and comprised of pure holstein-fr...

2011
Søren Lindemose Peter Eigil Nielsen Morten Hansen Niels Erik Møllegaard

The double-stranded DNA of the genome contains both sequence information directly relating to the protein and RNA coding as well as functional and structural information relating to protein recognition. Only recently is the importance of DNA shape in this recognition process being fully appreciated, and it also appears that minor groove electronegative potential may contribute significantly in ...

2012
Yuan-Ping Pang Haiming Dai Alyson Smith X. Wei Meng Paula A. Schneider Scott H. Kaufmann

Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to initiate Bak homo-oligomerization. However, it is unclear how such tight binding can induce Bak homo-oligomerization. Here we report the ligand-induced Bak conformational changes observed in 3D models of Noxa·Bak and Bim·Bak refined by molecular dynamics simulations. In ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه رازی - دانشکده علوم 1388

افزایش dna به محلول لیگاند شیف باز موجب کاهش شدت جذب در اسپکتروفتومتری لیگاند ، افزایش ویسکوزیته محلول، افزایش در طیفهای فلورسنس و تغییرات کانفورماسیونی شدید در طیف دورنگ نمایی چرخشی dna شده است. این نتایج نشان دادند که این لیگاند شیف باز می‏تواند به طریق intercalation با dna برهم‏کنش بدهد. نتایج ژل الکتروفورز نیز نشان دادند که این لیگاند قادر به ایجاد cleavage در puc 18 plasmid dna می باشد. ا...

Journal: Journal of Nanoanalysis 2018

In this study, we were synthesized Fe3O4@LDH@Lamivudine and characterized by FT-IR spectroscopy,XRD and TEM. The interaction of this nanoparticle with CT-DNA was investigated by viscosity, circulardichroism (CD), Uv-Visible and fluorescence spectroscopy. Among all nanocarriers which applied as drugdelivery vectors, layered double hydroxides (LDHs) with exchangeable anions in t...

Journal: :Biochemistry 2005
Michael E Budiman Ulrich Bierbach Rebecca W Alexander

PT-ACRAMTU ([PtCl(en)(ACRAMTU-S)](NO(3))(2), en = ethane-1,2-diamine, ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) is a cytotoxic platinum-acridine conjugate previously shown to form adducts with the N3 endocyclic nitrogen of adenine in the DNA minor groove. This unusual observation and our prior determination of the pronounced 5'-TA/TA base-step affinity of the drug have prom...

Journal: :Journal of molecular biology 2007
Peter L Privalov Anatoly I Dragan Colyn Crane-Robinson Kenneth J Breslauer David P Remeta Conceição A S A Minetti

The energetic profiles of a significant number of protein-DNA systems at 20 degrees C reveal that, despite comparable Gibbs free energies, association with the major groove is primarily an enthalpy-driven process, whereas binding to the minor groove is characterized by an unfavorable enthalpy that is compensated by favorable entropic contributions. These distinct energetic signatures for major ...

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