[chemical reaction: see text]. Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nuc...

Aliphatic ,w-dibromides can be converted to the corresponding c,w-di—Grignard reagents; for those members carrying less than four carbon atoms between the functions, special procedures are required. The synthesis, structure and applications of the di-Grignard reagents are discussed; particular emphasis is placed on the structures of the corresponding cyclic dialkylmagnesiums, and on the use of ...

Homocoupling reactions of aryl, alkenyl, and alkynyl Grignard reagents are an easy and efficient access to symmetrical dior polyaromatic, olefinic, or acetylenic conjugated compounds. The potential applications of such compounds in optical materials, molecular devices, and organic conductors are well-recognized.1 Therefore, for large-scale applications, it is interesting to develop more conveni...

An efficient enantioselective synthesis of lactones was developed based on the catalytic asymmetric conjugate addition (ACA) of alkyl Grignard reagents to pyranones. The use of 2H-pyran-2-one for the first time in the ACA with Grignard reagents allows for a variety of further transformations to access highly versatile building blocks such as β-alkyl substituted aldehydes or β-bromo-γ-alkyl subs...

A new convenient, functional group-tolerant, transition metal-free route to aryl trifluoromethyl ketones under mild conditions is described. The reaction of not only aryl Grignard reagents carrying reducible electrophilic functional groups, such as ester and cyano groups, but also electron-deficient nitrogen-containing heteroaryl Grignard reagents with methyl trifluoroacetate gives the correspo...

The mixed diaryl titanates were used for the first time to modify the reactivity of two aryl Grignard reagents. Two titanate intermediates, Ar[Ar'Ti(OR)3]MgX and Ar'[ArTi(OR)3]MgX, formed via alternating the sequence of combining Grignard reagents with ClTi(OR)3 showed a significant reactivity difference. Taking advantage of such different reactivity, two highly structurally similar aryl groups...

It is no longer necessary to use dialkylzinc reagents to obtain enantioselectivities >95% in the copper-catalyzed asymmetric conjugate addition of organometallic compounds to cyclic enones. We now report how this can be accomplished by using inexpensive and readily available Grignard reagents. Screening of bidentate ligands provided outstanding results with copper complexes of commercially avai...

___________________________________________________________________________________________ Abstract Although iron was known and widely used by people for hundreds of years, Grignard reagents also used for about a century, binding together these two concepts still took a long time and surprisingly it did not become a hot topic in chemistry until this decade. This paper is presenting several dev...

the insertion of an olefinic c=c bond into a metal-carbon bond is of potential interest as a preparativeroute to new products and as results of c-c coupling reactions to organic compounds. the allyl compoundsof mg, react with an olefin by inversion of the allyl group via a six center transition state. these precyclicreactions may be one of the most important classes of organic reactions. the re...