We present a case study in confronting the GPT generalpurpose planner with the challenging power supply restoration (PSR) benchmark for contingent planning. PSR is derived from a real-world problem, and the dif£culty of modeling and solving it contrasts with that of the purely arti£cial benchmarks commonly used in the literature. This confrontation leads us to improve general techniques for con...

UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase (GPT) is the first enzyme in the dolichol pathway of protein N-glycosylation, and is implicated in the developmental programmes of a variety of eukaryotes. In the present study we describe the effects of all-trans-retinoic acid (RA) on the levels of GPT protein and enzymic activity, and on the transcription r...

Background: Glyphosate (GPT) is a broad-spectrum systemic herbicide used to kill weeds, especially annual broadleaf and grasses known to compete with commercial crops grown around the globe. According to United States environmental protection agency the chemical has been reported as a third class toxin. Present study was designed in order to evaluate GPT-induced detrimental effects on testicula...

GlcNAc-1-P transferase (GPT) transfers GlcNAc-1-P from UDP-GlcNAc to dolichol-P (Dol-P), forming GlcNAc-P-PDol to initiate synthesis of the lipid-linked oligosaccharide Glc3Man9GlcNAc2-P-P-dolichol (G3M9Gn2-P-P-Dol). Elevated expression of GPT in CHO-K1 cells is known to cause accumulation of the intermediate M5Gn2-P-P-Dol, presumably by excessively consuming Dol-P and thereby hindering Dol-P-d...

The developmental and hormonal regulation of UDP-GlcNA:dolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT), the enzyme which initiates the biosynthesis of asparagine-linked glycoproteins, was investigated in mouse mammary glands. An anti-peptide antibody raised against the carboxyl-terminal 11 amino acids of mouse GPT, immunoadsorbed GPT activity and recognized a protein of exp...

The present study delineates the cellular responses of dorsal pallium to targeted genetic ablation of the principal preplate neurons of the neocortex. Ganciclovir treatment during prenatal development (E11-E13; where E is embryonic day) of mice selectively killed cells with shared S-phase vulnerability and targeted expression of a GPT [golli promoter transgene, linked to HSV-TK (herpes simplex ...

M e t h o d s Design: Randomized controlled trial (Standard and New Antiepileptic Drugs [SANAD] trial, Arm A) Allocation: Concealed.* Blinding: Unblinded.* Follow-up period: Up to 6 years. Setting: Hospital-based outpatient clinics in the United Kingdom. Patients: 1721 patients (mean age 38 y, 55% men) who had ≥ 2 clinically definite, unprovoked epileptic seizures in the past year and were reco...

Field testing of a proprietary stormwater treatment device (GPT) was undertaken over a one year period at a commercial site located in Sippy Downs, Queensland. The focus of the study was primarily on evaluating the effectiveness of the GPT device in removing pollution in the form of nutrients (Total Suspended Solids, Total Nitrogen, Total Phosphorus) from stormwater runoff. Water quality analys...

General purpose technologies (GPTs) are drastic innovations, such as electrification, the transistor, and the Internet, that are characterized by the pervasiveness in use, innovational complementarities, and technological dynamism. The transitional and long-run dynamic effects of a GPT are analyzed within a quality-ladders model of scale-invariant Schumpeterian growth. The diffusion path of a G...

Adenovirus E1A gene products are capable of modulating the expression of a variety of integrated genes. To study the mechanisms by which this regulation occurs, recombinant retroviruses have been utilized to establish cell lines containing an integrated copy of either the adenovirus E2 or E3 promoter adjacent to the bacterial guanine phosphoribosyl transferase (GPT) gene. These cell lines have ...