نتایج جستجو برای: gpr 119
تعداد نتایج: 17385 فیلتر نتایج به سال:
غربالگری مجازی بر اساس ساختار و لیگاند و مطالعه کیوسار سه بعدی برای شناسایی آگونیست های جدید gpr 119
گیرنده جفت شده پروتئین g 119 (gpr 119) یک هدف جالب و امیدوارکننده برای درمان بیماری دیابت نوع 2 (t2dm) است. در این تحقیق، روابط کمّی ساختار- فعالیت سه بعدی، الحاق کردن مولکولی و غربالگری مجازی بر روی یک سری از آگونیست های جدید gpr 119 انجام شد. نتایج، توانایی پیش بینی و قابلیت اطمینان بالایی از مدل ها را نشان داد. یک مدل فارماکوفوری کیفی با استفاده از الگوریتم hip-hop ساخته شد. این مدل رضایت بخش...
ground penetrating radar (gpr) method as a high resolution non-destructive geophysical method is used for detection of shallow subsurface targets. this method is based on the transmission of electromagnetic waves inside the earth and recording the reflected waves from the subsurface. as the method uses high-frequency electromagnetic waves in the frequency ranges of 12.5 to 2500 mhz (called gpr ...
During germination of spores of Bacillus species the degradation of the spore's pool of small, acid-soluble proteins (SASP) is initiated by a protease termed GPR, the product of the gpr gene. Bacillus megaterium and B. subtilis mutants with an inactivated gpr gene grew, sporulated, and triggered spore germination as did gpr+ strains. However, SASP degradation was very slow during germination of...
TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti-GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on a subset of memory alpha4beta7(high) intestinal trafficking CD4 and CD8 lymphocytes. In additi...
روش رادار نفوذی به زمین (gpr) یک روش ژئوفیزیکی غیر مخرب است که قادر به آشکارسازی انواع ناهمگنی های زیرسطحی و نیز شناسایی انواع اهداف مدفون در اعماق کم است. در پژوهش حاضر مدل سازی پیشرو و وارون داده های gpr با هدف کاربرد در زمینه باستان شناسی، انجام شده است. منطقه مورد مطالعه، منطقه باستانی تپه حصار دامغان است که در این منطقه با هدف بررسی های باستان شناسی زیرسطحی، تعدادی پروفیل gpr با استفاده از...
Cell divisions are sometimes oriented by extrinsic signals, by mechanisms that are poorly understood. Proteins containing TPR and GoLoco-domains (C. elegans GPR-1/2, Drosophila Pins, vertebrate LGN and AGS3) are candidates for mediating mitotic spindle orientation by extrinsic signals, but the mechanisms by which TPR-GoLoco proteins may localize in response to extrinsic cues are not well define...
Cytokinesis and spindle positioning require the cortical force regulator G Protein Regulator 1/2 (GPR-1/2). GPR-1/2 is thought to localize to sites of cortical force generation. Does GPR-1/2 also act as a sensor for mechanical stimulation? I mechanically stimulated the cortex by indenting it with a glass needle and observed the cortical localization of a YFP::GPR-1 transgene. I found that corti...
The shape and feature extraction in Ground Penetrating Radar (GPR) data is the most addressed application in present underground object identification technique. The problem of automatically detecting the shape and feature in GPR data is in analysing and fitting the hyperbola features from GPR data objects. To address these, we propose a hyperbole fitting method to extract the shape and feature...
Ground penetrating radar (GPR) has emerged as an effective tool for estimating active layer thickness (ALT) and volumetric water content (VWC) within the active layer. In August 2013, we conducted a series of GPR and probing surveys using a 500 MHz antenna and metallic probe around Barrow, Alaska. We collected about 15 km of GPR data and 1.5 km of probing data. Here, we describe the GPR data pr...
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