نتایج جستجو برای: gpcr

تعداد نتایج: 4523  

Christine Edwards, Christopher A Reynolds, Nikzad Nikbin,

A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...

Abstract- Efficient message delivery in city environment is required to ensure driver’s safety and passenger’s comfortability. In cities of developed nations, routing of data in vehicular Ad hoc Network (VANET) faces many challenges such as radio obstacles, mobility constraints and uneven nodes distribution. These factors primarily makes communication between vehicles complex. To overcome and t...

Journal: :Acta Crystallographica Section A Foundations of Crystallography 2011

Journal: :Bioinformatics 2010
George Khelashvili Kevin C. Dorff Jufang Shan Marta Camacho-Artacho Lucy Skrabanek Bas Vroling Michel Bouvier Lakshmi Devi Susan R. George Jonathan A. Javitch Martin J. Lohse Graeme Milligan Richard R. Neubig Krzysztof Palczewski Marc Parmentier Jean-Philippe Pin Gert Vriend Fabien Campagne Marta Filizola

SUMMARY Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB ...

Journal: :Journal of translational autoimmunity 2021

Impairment of health after overcoming the acute phase COVID-19 is being observed more and frequently. Here different symptoms neurological and/or cardiological origin have been reported. With symptoms, which are very similar to ones reported but not caused by SARS-CoV-2, occurrence functionally active autoantibodies (fAABs) targeting G-protein coupled receptors (GPCR-fAABs) has discussed be inv...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Tejas M Gupte Rabia U Malik Ruth F Sommese Michael Ritt Sivaraj Sivaramakrishnan

Although individual G-protein-coupled receptors (GPCRs) are known to activate one or more G proteins, the GPCR-G-protein interaction is viewed as a bimolecular event involving the formation of a ternary ligand-GPCR-G-protein complex. Here, we present evidence that individual GPCR-G-protein interactions can reinforce each other to enhance signaling through canonical downstream second messengers,...

2013
Honoo Satake Shin Matsubara Masato Aoyama Tsuyoshi Kawada Tsubasa Sakai

A G protein-coupled receptor (GPCR) functions not only as a monomer or homodimer but also as a heterodimer with another GPCR. GPCR heterodimerization results in the modulation of the molecular functions of the GPCR protomer, including ligand binding affinity, signal transduction, and internalization. There has been a growing body of reports on heterodimerization of multiple GPCRs expressed in t...

2013
Zaichao Zhang Jiayan Wu Jun Yu Jingfa Xiao

G-protein couple receptors (GPCR) possess diversified functions and they comprise a large protein superfamily in cellular signaling. Numerous identification methods for GPCR have been employed and versatile GPCR types are discussed. Although they share conserved transmembrane structural topology, alignment results of all GPCR show no significant sequence similarities. Each GPCR type distributes...

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی تهران 1345

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