1. Hypertension was induced in rats by renal artery clip with the contralateral kidney removed (Goldblatt I) or left intact (Goldblatt II). 2. Plasma noradrenaline was increased 62% in the Goldblatt I animals after 3 weeks. 3. Hypothalamic tyrosine hydroxylase and dopamine beta-hydroxylase activities, and the concentration of noradrenaline were increased in the Goldblatt I animals after 3 weeks...

1. Restriction of dietary salt intake does not affect the development or maintenance of hypertension in rats with unilateral renal ischaemia whether the contralateral kidney is present (Goldblatt 2 model) or not (Goldblatt 1 model). 2. Acute dietary salt depletion induces a similar loss of sodium and fall in body weight with little change in blood pressure in both normal and hypertensive rats. ...

background: ferula persica has been used in traditional medicine for treatment of high blood pressure. in this study acute and chronic effect of aqueous f. persica extract on bp of hypertensive rats and its possible mechanism of action have been investigated. methods: eighty two male wistar rats were divided into 12 experimental groups. hypertension was induced by goldblatt method in the anesth...

TO THE EDITOR: Glodny and Glodny (1) state that first John Loesch and then our father, Harry Goldblatt, published papers with the same “central proposition”: “Renal ischemia causes persistent hypertension.” They also state that because of the “primacy” of his observations, Loesch should be recognized as the “discoverer of renovascular hypertension.” Earlier, Theodor Fahr suggested that “renal i...

Renovascular hypertension is counted among the surgically curable hypertensions, and occupies from 5 to 20per cent of all hypertensions (UENO et al. 1965). Its mechanism is the same as the Goldblatt hypertension (GOLDBLATT et al. 1934), whose vascular lesion can gradually advance, until it becomes refractory to all surgical procedures, if it is left untreated. These circumstances will be greatl...

1. Removal of the renal artery constriction but not of the clipped kidney restored the blood pressure to normal levels in Goldblatt two-kidney rats with hypertension of more than 4 months' duration. 2. Despite the differences in blood pressure response, both surgical procedures lowered plasma renin concentration to normal or below normal values. 3. Administration of the oral converting enzyme i...

1. Urinary kallikrein, renal tissue kininogenase activity, and plasma kininogen were measured during the development of hypertension in rats, either with left renal artery clamped and contralateral kidney intact (Goldblatt 2-kidney) or removed (Goldblatt 1-kidney). Plasma urea, plasma volume and blood volume were also measured. 2. In Goldblatt 2-kidney rats, urinary kallikrein was not Significa...

The renal microcirculation was assessed in non-clipped kidneys of 23 Munich-Wistar rats with two-kidney one-clip Goldblatt hypertension. Four weeks after placement of a renal arterial clip, mean systemic arterial pressure averaged 163 ± 5 mm Hg in hypertensive rats as compared to 108 ± 2 in sham-operated controls (n = 6 rats). Non-clipped kidneys in hypertensive rats were characterized by highe...

To determine the role of vasopressin in the maintenance of high blood pressure, the antihypertensive effect of the antagonists of the vasopressor effect of vasopressin, [1-deaminopenicillamine, 4-valine, 8-D-arginine] vasopressin (dPVDAVP), and [1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic acid), 4-valine, 8-D-arginine] vasopressin (cyclo dVDAVP), was studied in unanesthetized, nons...