نتایج جستجو برای: glycogen synthase kinase 3 beta
تعداد نتایج: 2182353 فیلتر نتایج به سال:
background: the wnt/β- the wnt/β-catenin signaling pathway is involved in many developmental processes in both fetal and adult life; its abnormalities can lead to disorders including several types of cancers and malfunction of specific cells and tissues in both animals and humans. its role in reproductive processes has been proven. objective: this study was designed to evaluate the expression o...
background: salivary gland tumors (sgt) are rare lesions with uncertain histopathology. one of the major signaling pathways that participate in the development of several tumors is protein kinase a. in this pathway, glycogen synthase kinase β (gsk3β) and camp responsive element binding protein (creb3) are two genes which are supposed to be down regulated in most human tumors. the expression lev...
Background: Atrophy in skeletal muscle plays an important role in disease-related tissue dysfunction such as sarcopenia. The Wnt-signaling pathway has been shown to be critical for skeletal muscle development. Current evidence suggests that exercise trainings may alter hypertrophy-related signaling in skeletal muscle. Therefore, the purpose of this study was investigating the effect of three mo...
Kinases can phosphorylate and regulate androgen receptor activity during prostate cancer progression. In particular, we showed that glycogen synthase kinase-3 beta phosphorylates the androgen receptor, thereby inhibiting androgen receptor-driven transcription. Conversely, the glycogen synthase kinase-3 beta inhibitor lithium chloride suppressed the glycogen synthase kinase-3 beta-mediated phosp...
Phosphorylation of beta-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes beta-catenin for subsequent phophorylation by glycogen synthase kinase 3.
Inactivation of nuclear GSK3beta by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response" (2016). Davis Lab.
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being and survival of elderly individuals worldwide. NDDs include Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), amyotrophic lateral sclerosis (ALS), so on. They are characterized by progressive loss or dysfunction neurons in central peripheral nervous system share several cellular molecular mech...
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