OBJECTIVE In the light of the reported inconsistent anti-ischaemic and antianginal effects of transdermal glyceryl trinitrate, its efficacy and influence on the effects of intracoronary glyceryl trinitrate were examined during coronary angioplasty, which provides a model of controlled, reversible ischaemia. DESIGN Double blind, randomised study of the effect of transdermal and intracoronary g...

to the degree of coronary narrowing, 47 consecutive chest pain patients were studied without premedication by analysing selective coronary angiograms before and after glyceryl trinitrate. Proximal coronary diameters were measured in superimposed frames with callipers. Lumen diameter increased after glyceryl trinitrate 15 ± 2 per cent in the left main, 18 ± 2 per cent in the left anterior descen...

Cerebral malaria (CM) is associated with low nitric oxide (NO) bioavailability, cerebrovascular constriction, occlusion, and hypoperfusion. Administration of exogenous NO partially prevents the neurological syndrome and associated vascular pathology in an experimental CM (ECM) mouse model. In this study, we evaluated the effects of transdermal glyceryl trinitrate in preventing ECM and, in combi...

Background—Nitric oxide is a major neurotransmitter in non-adrenergic, noncholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. Aims—To study the eVect of glyceryl trinitrate, a nitric oxide donor, on gall bladder emptying in healthy subjects using a randomised,...

Changes in left ventricular size may be of importance in the development of angina and in its amelioration by glyceryl trinitrate, but left ventricular dimensions have not been measured during exercise in the upright position, the circumstance in which angina most often occurs. To assess changes in left ventricular end-systolic and end-diastolic dimensions, echocardiograms were obtained from 5 ...

BACKGROUND Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS To study the effect of glyceryl trinitrate, a nitric oxide donor, on gall bladder emptying in healthy subjects using a randomi...

OBJECTIVE To assess the diagnostic value and safety of sublingual glyceryl trinitrate tilt testing compared with isoprenaline infusion in patients with unexplained syncope. DESIGN Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and controls. SETTING Outpatient cases with syncope referred to Shahid Rajaii Heart Hospital. SUBJ...

Objective—To assess the diagnostic value and safety of sublingual glyceryl trinitrate tilt testing compared with isoprenaline infusion in patients with unexplained syncope. Design—Glyceryl trinitrate and isoprenaline tilt tests were performed in two successive days on a random basis in cases and controls. Setting—Outpatient cases with syncope referred to Shahid Rajaii Heart Hospital. Subjects—6...

OBJECTIVE To investigate whether the susceptibility to tolerance to glyceryl trinitrate is similar in different vascular beds in patients with chronic heart failure. PATIENTS Twenty patients with heart failure underwent a continuous infusion of glyceryl trinitrate over 24 hours followed by administration of N-acetylcysteine (5 g intravenously) in a bolus. MAIN OUTCOME MEASURES Haemodynamic ...