we have investigated the preventive effects of oral administration of isolated e.coli ghttam'tc acid decarboxylase (gad) in animal models. based on our results, the blood glucose levels were reduced by oral administration of gad to rats 14 days before intraperitoneal injections of streptozocin (40 mg/kg on five consecutive days). on the other hand, oral administration of gad to rats before stre...

background: l-glutamic acid is one of the major amino acids that is present in a wide variety of foods. it is mainly used as a food additive and flavor enhancer in the form of sodium salt. corynebacterium glutamicum (c. glutamicum) is one of the major organisms widely used for glutamic acid production. methods: the study was dealing with immobilization of c. glutamicum and mixed culture of c. g...

a facile one step synthesis of anilino alky1-n-substituted phthalimide i is reported. the following compounds belonging to this series were made: 1. (anilino-n-ethyl) phthalimide 8 2. (3,4, 5-trimethoxy anilino-n-ethyl) phthalimide 6 3. (3,4, 5-trimethoxy anilino-n-propyl) phthalimide 7 4. n-(ethyl phthalirnido-p-amino benzoyl) glutamic acid diethyl ester 10 5. n-(propyl phthalimido-p-amino ben...

background: autoimmune type 1 diabetes mellitus is caused by t-cell mediated immune destruction of the insulin-producing β-cell in pancreatic islets of langerhans. specificity of the auto-antibodies and of the auto-reactive t-cells has been investigated, in which several auto-antigens were proposed. objective: to determine whether glutamic acid decarboxylase (gad) feeding would induce oral tole...

the diabetes is an autoimmune disease, in which the role of autoantibodies is of a specific importance. the appearance of these autoantibodies can be the first symptom in the serum of type i diabetic patients, which may appear ten years before onset of the disease. the most important autoantibodies include glutamic acid decarboxylase autoantibodies (gad65-ab). this can be used as a good tool fo...

in this study, the synthesis of 4 h -chromenes of biological activity via a multicomponent reaction of dimedone, aromatic aldehydes and malononitrile catalyzed by glutamic acid as a catalyst was investigated. the structural features of the synthesized compounds were characterized by melting point, ir and 1 h nmr analysis. the catalyst being reported here is cheap, safe to handle and the whole p...

A facile one step synthesis of anilino alky1-N-substituted phthalimide I is reported. The following compounds belonging to this series were made: 1. (anilino-N-ethyl) phthalimide 8 2. (3,4, 5-trimethoxy anilino-N-ethyl) phthalimide 6 3. (3,4, 5-trimethoxy anilino-N-propyl) phthalimide 7 4. N-(ethyl phthalirnido-p-amino benzoyl) glutamic acid diethyl ester 10 5. N-(propyl phthalimido-p-ami...

Corynebacterium glutamicum is a biotin auxotroph that secretes L-glutamic acid in response to biotin limitation; this process is employed in industrial L-glutamic acid production. Fatty acid ester surfactants and penicillin also induce L-glutamic acid secretion, even in the presence of biotin. However, the mechanism of L-glutamic acid secretion remains unclear. It was recently reported that dis...

Cell suspensions derived from a mouse plasmacytoma (RPC-20) that secretes an immunoglobulin light chain containing N-terminal pyroglutamic acid can synthesize protein in vitro. Chromatographic examination of an enzymatic digest of protein labeled with glutamic acid shows only labeled glutamic acid and pyroglutamic acid; hydrolysis of protein from cells labeled with glutamine, however, yields su...