results comparative analysis of predicted amino acids in the phylogenetic tree showed high similarity between c. glabrata and s cerevisiae. besides, c. glabrata demonstrated the capability to grow in glucose levels as low as 0.01% in the spot dilution assay. in qrt-pcr analysis, differential expressions were observed in selected genes when c. glabrata was subjected to different glucose concentr...

Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins...

background: glucose uptake by muscles and fat cells is carried out by the glut4 system. isoforms of the snap23, syntaxin-4 and vamp-2 play an important role in regulating glut-4 trafficking and fusion in adipocytes. the changes of snare proteins levels and thus impaired glut-4 displacement can be one of the etiological causes of type 2 diabetes. due to changes in the expression of these protein...

Glucose is the major energy source for the animal cells. It is important substrate for protein and lipid synthesis. This sugar is absorbed into the cells from body fluids via glucose transporters – structurally related trans-membrane proteins. There are two types of glucose transport passive and active. The facilitative-glucose-transporter family of proteins (solute co-transporters GLUT, encode...

A 729-bp open reading frame (gltR) was identified in Pseudomonas aeruginosa PAO1 that encodes a product homologous to the two-component response regulator family of proteins. Disruption of gltR caused loss of glucose transport activity. Restoration of gltR resulted in wild-type levels of glucose transport. These findings indicate that gltR is required for expression of the glucose transport sys...

Glucose transporters (GLUT) are twelve-transmembrane spanning proteins that contain two pores capable of transporting glucose and dehydroascorbate in and out of cells. The mechanism by which transport is effected is unknown. An evolutionarily-based hypothesis for the mechanism of glucose transport is presented here based on reports that insulin has multiple binding sites for glucose. It is prop...

SGLT1 is a sodium/glucose cotransporter that moves two Na(+) ions with each glucose molecule per cycle. SGLT3 proteins belong to the same family and are described as glucose sensors rather than glucose transporters. Thus, human SGLT3 (hSGLT3) does not transport sugar, but extracellular glucose depolarizes the cell in which it is expressed. Mouse SGLT3b (mSGLT3b), although it transports sugar, h...

Malignant cells are known to have accelerated metabolism, high glucose requirements, and increased glucose uptake. Transport of glucose across the plasma membrane of mammalian cells is the first rate-limiting step for glucose metabolism and is mediated by facilitative glucose transporter (GLUT) proteins. Increased glucose transport in malignant cells has been associated with increased and dereg...