نتایج جستجو برای: glioblastomamultiforme
تعداد نتایج: 18 فیلتر نتایج به سال:
Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastomamultiforme cells
Glioblastoma, the most frequent primary brain tumor and the most malignant neoplasm, can have the most heterogeneous morphological presentation. Along with classical morphological features, areas of oligodendroglial component and mesenchymal differentiation may be seen. The present case was a rare case of glioblastoma presenting with sarcomatous and oligodendroglial components. The case was dia...
background: broca’s and wernicke’s areas, which are important language areas of brain, are commonly irradiated in patients with right frontal lobe glioblastomamultiforme (gbm). we aimed to compare two different treatment planning techniques in terms of the doses in the broca’s and wernicke’s areas for the patients with right frontal gbm. materials and methods: two different treatment planning t...
DNA sequencing offers a powerful tool in oncology based on the precise definition of structural rearrangements and copy number in tumor genomes. Here, we describe the development of methods to compute copy number and detect structural variants to locally reconstruct highly rearranged regions of the tumor genome with high precision from standard, short-read, paired-end sequencing datasets.Wefind...
Glioblastomamultiforme (GBM) is themost common formofbrain tumorwith apoorprognosis and resistance toradiotherapy.Recentevidencesuggests thatglioma-initiatingcellsplayacentral role inradioresistance through DNAdamage checkpoint activation and enhanced DNA repair. To investigate this inmore detail, we compared the DNA damage response in nontumor forming neural progenitor cells (NPC) and glioma-i...
Glioblastomamultiforme (GBM) is one of themost aggressive human tumorswith apoor prognosis. Current standard treatment includes chemotherapy with the DNA-alkylating agent temozolomide concomitant with surgical resection and/or irradiation.However, anumber of cases are resistant to temozolomide-inducedDNA damage due to elevated expression of the DNA repair enzyme O-methylguanine-DNA methyltransf...
Purpose: Glioblastoma multiforme is a deadly primary brain cancer. Because the tumor kills due to recurrences, we tested the hypothesis that a new treatment would lead to immunological memory in a rat model of recurrent glioblastoma multiforme. Experimental Design: Wedeveloped a combined treatment using an adenovirus (Ad) expressing fms-like tyrosine kinase-3 ligand (Flt3L), which induces the i...
Glioblastomamultiforme (GBM) is one of the most lethal forms of cancer, with a survival rate of only 13% to 27%within 2 years of diagnosis despite optimal medical treatment. We hypothesize that the presence of a unique IL-13Ra2 decoy receptor prevents GBM apoptosis. This receptor has a high affinity for interleukin13 (IL-13), binds the cytokine, and competitively inhibits the intracellular sign...
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