brain tumors are considered in regarded to their size, position and aggressive manner. brain tumors cause several neurologic symptoms. for instance, they increase intracranial pressure due to local damage and displacement of surrounding tissues. in this paper, two glioblastoma multiform cases with more than 15 year- survival have been reported. the first patient was a 52 year- old woman who suf...

background & aim: glioblastoma multiforme (gbm), the highest grade glioma (grade iv), is the most malignant form of astrocytoma in adults. this study aimed at evaluating the relationship between demographic, clinical and medical factors with gbm outcome. methods & materials/patients: through a cross-sectional design, 58 patients with newly diagnosed gbm were studied from 1999 to 2015 in guilan ...

radiation induced sarcoma is a rare but recognized complication of radiotherapy and is associated with poor prognosis, frequently occurs 5 years after completion of treatment. we report radiation-induced sarcoma in a 42 years old male, involving the left parietooccipital scalp region following treatment of brain tumor with craniotomy and post-operative radiation with 60co machine. diagnosis of ...

Background: Since EGFR inhibitors show a limited therapeutic effect on Glioblastoma multiforme patients, the EGFR/MAPK/STAT5/FN14 signaling pathway becomes vulnerable to invasive GBM cell population and may be suitable target for treatment of GBM. Nanocurcumin consumption exercise training are probably effective interventions in this pathway. Objectives: This study aimed investigate simultaneou...

Purpose: The study was initiated to obtain epidemiologic data and information on anatomic distribution, clinical features and treatment results in patients with primary supratentorial anaplastic astrocytoma and glioblastoma multiform. Patients and Methods: Between January 2000 and January 2006, 113 primary high grade astrocytoma patients were eligible to evaluate clinical features. Radiotherapy...

Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radio...

Diffuse large cell non Hodgkin's lymphoma associated with chronic lymphoid leukemia (CLL), or Richter's syndrome, is a rare and serious complication. Isolated Richter's syndrome in the central nervous system is very rare; only 12 cases have been reported. We describe a 74-year-old patient with diffuse large cell non Hodgkin's lymphoma in the right frontal region with the appearance of multiform...