statement of problem: changes in protein levels, host calls enzymes and inflammatory mediators in gingival crevicular fluid (gcf) are considered as diagnostic indicators of periodontitis.purpose: he aim of the present study was to measure the elastase enzyme activity in gingival crevicular fluid among patients with periodontitis.material and methods: in this study, 52 periodontitis patients (ex...

interleukin-1β (il-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. the aim of this split-mouth study was to investigate the relationship between the concentration of il-1β in gingival crevicular fluid (gcf) and peri-implant crevicular fluid (picf) and clinical parameters such as plaque index (pi),...

objective: the gingival crevicular fluid (gcf) is an inflammatory exudate found in the gingival sulcus. the forces exerted during orthodontic treatment cause distortion of the periodontal ligament (pdl) extra-cellular matrix, resulting in some biological features that can lead to modification of both gcf volume and its components. the present study investigated the effect of orthodontic tooth m...

Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontitis whereas the latent enzyme is predominant in gingivitis. Since the activatio...

BACKGROUND AND OBJECTIVE Emdogain (EMD), consisting mostly of amelogenin, is used in periodontal therapy to regenerate lost connective tissue. Emdogain is applied onto periodontally affected root surfaces, where it becomes exposed to proteolytic enzymes. In this study, we aimed to find out whether gingival crevicular fluid or matrix metalloproteinases (MMPs) could degrade EMD, and whether this ...

Our studies aimed the eventual correlations of chemokines and interleukins levels (IFN-γ, IL-10, IL-2, IL-4, IL-5 and TNF-α) in serum and gingival crevicular fluid of patients with periodontitis and juvenile insulindependent diabetes mellitus as compared to periodontal healthy subjects (32 vs. 24 children and adolescents, respectively). The diabetic body interferences with microbiological micro...

Like other fluids of the human body, a gingival crevicular fluid (GCF) contains proteins, a diverse population of cells, desquamated epithelial cells, and bacteria from adjacent plaque. Proteomic tools have revolutionized the characterization of proteins and peptides and the detection of early disease changes in the human body. Gingival crevicular fluids (GCFs) are a very specific oral cavity f...

background: azithromycin (azm) is used in periodontal infections. the present study compared gingival crevicular fluid concentration of azithromycin of two pharmaceutical companies through the hplc method. methods: two groups (n=15) of healthy volunteers participated in this study. the first group received an imported azithromycin (imazm) tablet (250 mg, po) and the second group received an azi...

BACKGROUND Human cytomegalovirus (HCMV) infection is associated with renal transplant failure. Periodontal pockets may be reservoirs for HCMV replication. OBJECTIVES This study was done to determine active HCMV replication in saliva and gingival crevicular fluid of renal transplant patients affected by periodontitis. METHODS HCMV pp67-mRNA amplification was analyzed in oral fluids of 38 tra...