Aminoglycosides, such as gentamycin, are well known ototoxic agents. Toxicity occurs via an activation process involving the formation of an iron-gentamycin complex with free radical production. Antioxidants like Q-ter (a soluble formulation of coenzyme Q(10), CoQ(10)), can limit or prevent cellular ototoxic damage. The present study was designed to investigate the possible protective effects o...

BACKGROUND Malassezia pachydermatis is a yeast of importance in both veterinary and human medicine. AIMS To know if M. pachydermatis grow on mycological media with high concentrations of gentamycin. METHODS Twenty M. pachydermatis strains were streaked on Sabouraud Dextrose Agar plates with different concentrations of gentamycin. RESULTS All isolates were inhibited when high concentration...

AIM Gentamycin, a widely-used aminoglycoside antibiotic, is recognized as possessing significant nephrotoxic potential in human beings. Gentamycin-induced nephrotoxicity is suggested to be mediated via reactive oxygen species. The present study investigated the possible antioxidant nephroprotective effect of lacidipine as a calcium-channel blocker in a gentamycin-induced nephrotoxicity model in...

BACKGROUND/AIMS Motility is a feature of many pathogens that contributes to the migration and dispersion of the infectious agent. Whether gentamycin has a post-antibiotic effect (PAE) on the swarming and swimming motility of Escherichia coli (E. coli) remains unknown. In this study, we aimed to examine whether short-term pretreatment of sub-inhibitory concentrations of gentamycin alter motility...

Lactobacillus (L. casei) Zhang is a koumiss-originated probiotic strain, which was used as a model in a long-term antibiotics-driven evolution experiment to reveal bacterial evolutionary dynamics; and we isolated gentamycin-resistant L. casei Zhang descendents. To decipher the gentamycin resistance mechanism, here we cultivated the parental L. casei Zhang and its descendent cells in an antibiot...

Introduction: Acute tubular necrosis (ATN) is the most prevalent cause of acute renal failure (ARF). Mesenchymal stem cell transplantation has been studied as a potential treatment for renal dysfunction due to ATN. Inducible nitric oxide synthase (iNOS), bone morphogenetic protein-7 (BMP-7) and B-cell lymphoma 2 (Bcl-2) are surrogate markers of renal tubular epithelial regeneration and subseque...

Backgound: The major obstacle limiting the use of aminoglycoside, antibiotics has been and continues to be the possibility of drug induced ototoxicity and nephrotoxicity. Study dsign: Changes in biochemical parameters related to nephropathy before and after of nigella sativa were observed. Material and methods: Ten rabbits were included in the study, comprised as group 1 and 11. Group I was onl...

Background: The development of bacteria that have been resistant to antibiotics can complicate the treatment process. Either causes antibiotic resistance is inappropriate use antibiotics. Gentamycin an aminoglycoside-derived which its role very significant for gram-negative bacteria. Repeated gentamycin cause changes effectiveness so non ESBL-Gentamycin susceptible Escherichia Coli will change ...

Aim: The aim of this study was to investigate the protective effects of bioflavonoid compounds i.e. rutin and naringin on gentamycin induced testicular oxidative stress in rats. Method: A total of 42 male wistar albino rats were divided in to 7 groups, each contains 6 rats. Gentamycin, 5 mg/kg, I.P was administered to the rats from day 1 to day 10. Rutin and naringin were given in different dos...