Restriction enzymes are the workhorses of molecular biology. We introduce a new problem that arises in the course of our project to design virus variants to serve as potential vaccines: we wish to modify virus-length genomes to introduce large numbers of unique restriction enzyme recognition sites while preserving wild-type function by substitution of synonymous codons. We show that the resulti...

Motivated by the trend of genome sequencing without completing the sequence of the whole genomes, Muñoz et al. recently studied the problem of filling an incomplete multichromosomal genome (or scaffold) I with respect to a complete target genome G such that the resulting genomic distance between I ′ and G is minimized, where I ′ is the corresponding filled scaffold. We call this problem the one...

The papers in this issue address the field of animal biotechnology and, particularly, animal genomics. Together they seek to understand the context and shaping of the science of animal genomics, reflect on connections between this science and the social position and cultural construction of animals and human-animal relationships, and explore current and future regulation and policy. Each paper ...

Attaining high-quality corn silage is a critical aspect of profitability for corn and animal productivity. Biotechnology traits that reduce stress likely have more potential yield benefits for silage growers than even grain farmers. The corn genomes have been sequenced. We’ve put in thousands of markers that let us tag individual genes. Breeders have tools unlike anything they’ve had in the his...

extended abstract 1. introduction geopolitical genome is the potential of a country. as the genomics is the study of hundreds or perhaps thousands of simultaneous genetic reactions for identifying the main causes of disease and understanding the mechanism of an organism, the activation and extinguishing of the geopolitical genomes are those adopted policies based on the geographical and human p...

Cattle supply an important source of nutrition for humans in the world. CpG islands (CGIs) are very important and useful, as they carry functionally relevant epigenetic loci for whole genome studies. As a matter of fact, there have been no formal analyses of CGIs at the DNA sequence level in cattle genomes and therefore this study was carried out to fill the gap. We used hidden markov model alg...

Background: Antimicrobial resistance is a global problem with enormous public health and economic impact. This study was carried out to get an overview of acquired antimicrobial resistance gene sequences in the genomes of Escherichia coli isolated from different food sources and the environment in Nigeria. Methods: To determine the acquired antimicrobial-resistant genes prevalence, genome asse...