نتایج جستجو برای: genome editing
تعداد نتایج: 250036 فیلتر نتایج به سال:
leishmania is a protozoan parasite belonging to the family trypanosomatidae, which is found among 88 different countries. the parasite lives as an amastigote in vertebrate macrophages and as a promastigote in the digestive tract of sand fly. it can be cultured in the laboratory using appropriate culture media. although the sexual cycle of leishmania has not been observed during the promastigo...
Over the past decades, progression in genetic element manipulation, and consequently, the treatment of diseases has been remarkable. It is worth noting that these genetic manipulations perform at different levels, including DNA and RNA. The earlier genomic editing techniques, including MN, ZFN , TALEN , performing their functions by creating double-stranded breaks (DSBs), and after breakage, th...
conclusions our findings revealed that the zfn technology could be employed to overcome ampicillin resistance by the targeted disruption of the ampicillin resistance gene, which leads to inactivation of β-lactam synthesis. therefore, zfn technology could be engaged to decrease the antibiotic resistance issue with the construction of a zfn archive against different args. to tackle the resistance...
Objective(s): Oncolytic Herpes simplex virus type 1 (HSV-1) has emerged as a promising strategy for cancer therapy. However, development of novel oncolytic mutants has remained a major challenge owing to low efficiency of conventional genome editing methods. Recently, CRISPR-Cas9 has revolutionized genome editing.Materials and Methods: I...
Genome editing aims to revolutionise plant breeding and could assist in safeguarding the global food supply. The inclusion of a 12–40 bp recognition site makes mega nucleases first tools utilized for genome generation gene-editing tools. Zinc finger (ZFNs) are second technique, because they create double-stranded breaks, more dependable effective. ZFNs were original designed nuclease-based appr...
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