Genkwanin is one of the major non-glycosylated flavonoids in many herbs with anti-inflammatory activities. Although its anti-inflammatory activity in vivo has been reported, the potential molecular mechanisms remain obscure. In this study, by pharmacological and genetic approaches, we explore the anti-inflammatory effects of genkwanin in LPS-activated RAW264.7 macrophages. Genkwanin potently de...

Cytochrome P450 monooxygenases (CYP450s) are known to play important roles in biosynthesis of all secondary metabolites, including flavonoids. Despite this, few CYP450s have been functionally characterized in model plants and roles of fewer CYP450s are known in non-model, medicinal, and aromatic plants. Our study in Coleus forskohlii indicates that flavone synthase (CYP93B) and flavonoid 3' mon...

Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by recombinant CYP1A1, CYP1B1 and CYP1A2 enzymes, as well as their antiproliferative acti...

This paper reports on the in vitro antibacterial and in vivo anti-inflammatory properties of a hydroethanolic extract of the aerial parts of Gochnatia pulchra (HEGP). It also describes the antibacterial activity of HEGP fractions and of the isolated compounds genkwanin, scutellarin, apigenin, and 3,5-O-dicaffeoylquinic acid, as evaluated by a broth microdilution method. While HEGP and its fract...

Accurate (1)H chemical shifts of the -OH groups of polyphenol compounds can be calculated, compared to experimental values, using a combination of DFT, polarizable continuum model (PCM) and discrete solute-solvent hydrogen bond interactions. The study focuses on three molecular solutes: phenol, 4-methylcatechol and the natural product genkwanin in DMSO, acetone, acetonitrile, and chloroform. Ex...

the methanolic extract of the aerial parts of salvia leriaefolia (labiatae) afforded 5-hydroxy-4´, 6, 7-trimethoxy flavone (salvigenin) and (5,4´-dihydroxy-7-methoxy flavone (genkwanin). the structures of the isolated compounds were elucidated using 1 and 2 d-nmr, ir, uv and ms.

The methanolic extract of the aerial parts of Salvia leriaefolia (labiatae) afforded 5-hydroxy-4´, 6, 7-trimethoxy flavone (Salvigenin) and (5,4´-dihydroxy-7-methoxy flavone (Genkwanin). The structures of the isolated compounds were elucidated using 1 and 2 D-NMR, IR, UV and MS.

The methanolic extract of the aerial parts of Salvia leriaefolia (labiatae) afforded 5-hydroxy-4´, 6, 7-trimethoxy flavone (Salvigenin) and (5,4´-dihydroxy-7-methoxy flavone (Genkwanin). The structures of the isolated compounds were elucidated using 1 and 2 D-NMR, IR, UV and MS.

Candida albicans (C. albicans) is a fungus that causes candidiasis. C. has the enzyme Lanosterol 14- α demethylase. 14-α-demethylase bioactivity in converting lanosterol to ergosterol, special sterol found fungal membranes, which mediates membrane permeability and fluidity. One way treat candidiasis use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal med...