We can determine θs for pairs of genes or loci. Next question is how to place them in a genetic map; i.e., grouping loci into linkage groups and ordering sets of 3 or more loci. 1. Grouping loci into linkage groups The question beyond determining linkage of any two loci is the ordering of the loci into a reasonable genetic map. Ordering can be done using the MLE of θ, determined via a two-point...

Genetic maps are used routinely in family-based linkage studies to identify the rough location of genes that influence human traits and diseases. Unlike physical maps, genetic maps are based on the amount of recombination occurring between adjacent loci rather than the actual number of bases separating them. Genetic maps are constructed by statistically characterizing the number of crossovers o...

Over the past three decades, extensive genetic, physical, transcript, and sequence maps have assisted in the mapping of over 30 genetic diseases and in the identification of over 550 genes on human chromosome 14. Additional genetic disorders were assigned to chromosome 14 by studying either constitutional or acquired chromosome aberrations of affected subjects. Studies of benign and malignant t...

The construction of consensus genetic maps is a very challenging problem in computational biology. Many computational approaches have been proposed on the basis of only the marker order relations provided by a given set of individual genetic maps. In this article, we propose a comparative approach to constructing consensus genetic maps for a genome, which further takes into account the order re...