plants face many biotic and abiotic stresses at the same time during their growth under field conditions. plants responses toward combined stresses are often more complex than their responses to one type of stress in a way that the results of these responses are called as cross tolerance. this mixture of stresses activates specific models of gene expression that causes special signaling network...

background: prostate cancer is one of the most widespread cancers in men and is fundamentally a genetic disease. identifying regulators in cancer using novel systems biology approaches will potentially lead to new insight into this disease. it was sought to address this by inferring gene regulatory networks (grns). moreover, dynamical analysis of grns can explain how regulators change among dif...

objectives: epithelial-mesenchymal transition (emt) is a fundamental stage in cancer metastasis and the presence of vascular invasion is a strong indication of the spread of the malignant tumor cells. regulation of the emt is a complex process in which several different transcription factors are involved. eomesodermin (eomes) as a member of the t-box gene family is an important component in the...

amorpha-4, 11-diene synthase (ads) gene is the first and important gene in artemisinin biosynthesis pathway that why for many researchers, the study of how to regulate of this gene is important. transcription factors can change the expression rate of several genes simultaneously. in this study, six wild accessions of artemisia annua, collected from golestan province, were used. many known trans...

The response to drought stress is a complicated process involving stress sensing, intracellular signaltransduction, and the execution of a cellular response. Transcription factors play important roles in the signaling pathways including abiotic stress. In the present study a rice NF-YA transcription factor gene was partially characterized following dehydration. Disrupting the gene via a T...

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

retinal pigment epithelium is responsible for maintaining the structural integrity of the retina by an efficient defense against free radicals, photo-oxidative exposure and light energy. for this purpose the main rpe line of defense is melanosomes. melanin content of retinal pigment epithelium cells in adults and neonates reveals remarkable variations. in the current study we compared melanogen...