نتایج جستجو برای: gcb pwm

تعداد نتایج: 4927  

در این مقاله، یک استراتژی کنترلی تعمیم‌یافته از مدولاسیون پهنای پالس بر مبنای حامل (GCB-PWM) که برای مبدل‌های چندسطحی پشت به پشت مناسب می‌باشد، پیشنهاد گردیده است. هدف از روش پیشنهادی، ایجاد یک الگوی کلیدزنی به نحوی است که بدون افزایش فرکانس کلیدزنی، دامنه اولین هارمونیک حذف نشده ولتاژ خروجی، حذف شود یا به زیر حد مجاز استاندارد خود کاهش یابد. این امر با ثابت نگه‌داشتن اندیس مدولاسیون دامنه در م...

2012
Ying Huang Sheng Ye Yabing Cao Zhiming Li Jiajia Huang He Huang Muyan Cai Rongzhen Luo Tongyu Lin

Diffuse large B-cell lymphoma (DLBCL) can be molecularly subtyped as either germinal center B-cell (GCB) or non-GCB. The role of rituximab(R) in these two groups remains unclear. We studied 204 patients with de novo DLBCL (107 treated with first-line CHOP; 97 treated with first-line R-CHOP), patients being stratified into GCB and non-GCB on the basis of BCL-6, CD10, and MUM1 protein expression....

2009
Choladda V Curry April A Ewton Randall J Olsen Brent R Logan Hector A Preti Yao-Chang Liu Sherrie L Perkins Chung-Che Chang

Diffuse large B-cell lymphoma (DLBCL) with a germinal center B-cell (GCB) phenotype is believed to confer a better prognosis than DLBCL with an activated B-cell (ABC) phenotype. Previous studies have suggested that nuclear factor-kappaB (NF-kappaB) activation plays an important role in the ABC subtype of DLBCL, whereas c-REL amplification is associated with the GCB subtype. Using immunohistoche...

Journal: :International journal of clinical and experimental medicine 2015
Cheng Fang Danxia Zhu Huajie Dong Mei Ji Jun Wu Xiaoli Xu Gui Cheng Changping Wu Jingting Jiang

Lenalidomide has been shown to produce durable responses in patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL). In order to gain better understanding of the efficacy of lenalidomide and compared the difference in clinical outcome between two subtypes of DLBCL. Seven eligible trials involving 375 adult patients were included in this meta-analysis. The patients in non-germ...

Journal: :Blood 2004
Christine P Hans Dennis D Weisenburger Timothy C Greiner Randy D Gascoyne Jan Delabie German Ott H Konrad Müller-Hermelink Elias Campo Rita M Braziel Elaine S Jaffe Zenggang Pan Pedro Farinha Lynette M Smith Brunangelo Falini Alison H Banham Andreas Rosenwald Louis M Staudt Joseph M Connors James O Armitage Wing C Chan

Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like (GCB), activated B-cell-like (ABC), and type 3 gene expression profiles using a cDNA microarray. Tissue microarray (TMA) blocks were created from 152 cases of DLBCL, 142 of which had been successfully evaluated by cDNA microarray (75 GCB, 41 ABC, and 26 type 3). Sections...

Journal: :Journal of clinical and experimental hematopathology : JCEH 2017
Akifumi Ichiki Joaquim Carreras Masashi Miyaoka Yara Yukie Kikuti Tadashi Jibiki Kei Tazume Shigeki Watanabe Tamotsu Sasao Yoshiaki Obayashi Makoto Onizuka Ken Ohmachi Fumiaki Yoshiba Yukari Shirasugi Yoshiaki Ogawa Hiroshi Kawada Naoya Nakamura Kiyoshi Ando

The estimation of clinical prognosis for diffuse large B-cell lymphoma (DLBCL) with a quick, cost-efficient method is necessary because of the clinical heterogeneity of this disease, which leads to death, relapsed or refractory disease in approximately 40% of patients. We analyzed 320 cases diagnosed from 2007 to 2013 treated with R-CHOP therapy at Tokai University Hospital and associated insti...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2001
T De Pas G Curigliano L Franceschelli C Catania L Spaggiari F de Braud

Systemic capillary leak syndrome (SCLS) is a rare disorder with a high mortality rate, characterized by rapidly developing edema, weight gain and hypotension, hemoconcentration and hypoproteinemia. This syndrome is caused by sudden, reversible capillary hyperpermeability with a rapid extravasation of plasma from the intravascular to the interstitial space. Even though SCLS has been suggested to...

2014
Archana Pandita Bhupender Kumar Siddharth Manvati Samantha Vaishnavi Shashank K. Singh Rameshwar N. K. Bamezai

Gemcitabine, an effective agent in treatment of cancer of pancreas, has undergone failures in many instances after multiple cycles of therapy due to emergence of drug resistance. Combination of dietary compounds with clinically validated drugs has emerged as an effective therapeutic approach to treat pancreatic tumors, refractory to gemcitabine therapy. In order to optimize a possible synergist...

2013
Hiroko Toda Yasuharu Sato Katsuyoshi Takata Yorihisa Orita Naoko Asano Tadashi Yoshino

Diffuse large B-cell lymphoma (DLBCL) comprises 2 molecularly distinct subgroups of non-germinal center B-cell-like (non-GCB) and germinal center B-cell-like (GCB) DLBCLs, with the former showing relatively poor prognosis. In the present study, we analyzed the clinicopathological features of 39 patients with localized nasal/paranasal DLBCL. Immunohistochemistry-based subclassification revealed ...

Journal: :Polish journal of pathology : official journal of the Polish Society of Pathologists 2010
Joanna Jabłońska Dorota Jesionek-Kupnicka Piotr Potemski Artur Kowalik Jacek Sygut Radzisław Kordek

In this study we analyzed the prognostic value of single and combined immunohistochemical markers, according to algorithms proposed by Hans et al. and Muris et al. in 66 de novo diffuse large B-cell lymphoma (DLBCL) cases. The main aim of our study was to compare usefulness of these two immunohistochemical algorithms for the subdivision of DLBCL into prognostically relevant subgroups. Cases cla...

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