the majority of patients with glioblastoma multiforme (gbm) suffer dismal outcomes. adopting a broader, multi-mechanistic, multi-agent approach targeting gbm using readily available and fairly benign agents in combination with standard therapy may improve outcomes. such agents include fluoxetine, fenofibrate, cimetidine, citrulline, valacyclovir, 1,3 1-6 beta glucan, and tadalafil, among others...

background: gbm is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. several researchers around the world, including iran, have been investigated gbm-cell line in vitro. however in vivo studies have not been fulfilled. methods : as standard cell line (u-87mg) derived from human gbm and total gbm tumor derived from...

this paper investigates on control and stabilization of a new hyperchaotic system. the hyperchaotic system is stabilized using a new technique which called generalized backstepping method (gbm). because of its similarity to backstepping approach, this method is called gbm. but, this method is more applicable in comparison with conventional backstepping.  backstepping method is used only for sys...

background & aim: glioblastoma multiforme (gbm), the highest grade glioma (grade iv), is the most malignant form of astrocytoma in adults. this study aimed at evaluating the relationship between demographic, clinical and medical factors with gbm outcome. methods & materials/patients: through a cross-sectional design, 58 patients with newly diagnosed gbm were studied from 1999 to 2015 in guilan ...

conclusions test-retest and correlation analyses have identified non-redundant radiomics features and this feature are prone to errors if they employed as quantitative biomarker for gbm image analysis. however when we use robust and redundant feature, quantitative image radiomics features are informative and prognostic biomarkers for gbm magnetic resonance imaging. results results shows that th...

Inflammation has been closely related to various forms of brain tumors. However, there is little knowledge about the role of inflammation in glioma. Grade IV glioma is formerly termed glioblastoma multiform (GBM). GBM is responsible for over 13,000 deaths per year in the America. Magnetic resonance imaging (MRI) is the most commonly used diagnostic method for GBM tumors. Recently, use of the MR...

objective(s):p in vitro chemosensitivity and resistance assays (csras) are a promising tool for personalized treatment of glioblastoma multiform (gbm). these assays require a minimum of 1 to 2 g of tumor specimen for testing, but this amount is not always accessible. we aimed to assess the feasibility and validity of utilizing stereotactic biopsies of gbm in csras. materials and methods: single...

Introduction: Glioblastoma multiforme (GBM) is an aggressive case of primary brain cancer which remains among the most fatal tumors worldwide. Although, some in vitro and in vivo models have been developed for a better understanding of GBM behavior; a natural model of GBM would improve the efficiency of experimental models to human GBM tumors. We aimed at the present study to examine the surviv...

Introduction: Glioblastoma multiforme (GBM) is a highly radioresistant cancer with low survival rate. Current therapy approaches have failed to treat GBM. The aim of this study was to assess how GBM tumors respond to combination of hyperthermia and radiotherapy. Materials and Methods:   In this study, 38 GBM patients were included. 19 patients were treated ...

Number Treatment NumberOfPatients PatientCatagory Outcome 13014 Accelerated RT/Temodar 28 New GBM mPFS=6m, PFS6=48%, OS1yr=48%, OS2yr=8%. 2051 AMG-102 20 Recurrent GBM Response rate = 30% 13010 Avastin + chemo 34 Recurrent GBM PSF6=25%, mTTP=4m, mOS=7.5m. 2021 Avastin + CPT-11 35 Recurrent GBM PFS6=43%, OS6=74%, 2yrOS=15%. 2023 Avastin + CPT-11 44 Recurrent GBM mPFS=5.2m, mOS=9.0m. 13000 Avasti...