conclusions the comprehensive analysis of a protein with important roles has never been easy, and in case of e2 envelope glycoprotein of hgv, there is no much data on its molecular and immunological features, clinical significance and its pathogenic potential in hepatitis or any other gbv-c related diseases. so, results of the present study may explain some structural, physiological and immunol...

the hepatitis g virus (hgv) is a newly discovered rna virus, which is associated with acute or chronic hepatitis. a survey was conducted in thalassemic patients, intravenous drug users (ivdu) and blood donors aiming to investigate the prevalence of hepatitis g virus (hgv) infection in these groups in tehran. the presence of hgv rna in these populations was determined using reverse transcriptase...

conclusions overall, results of present study were consistent with the data reported earlier base on 5’ ntr in iranian isolates and revealed genotype ir2 is major genotype in iranian hgv-positive patient. it means there are higher similarities between iranian and europe-usa in hgv ns3 gene. results nucleotide blast results emphasized that most similar sequences to ir ns3 sequences were those fr...

conclusions this study found that gbv-c infection has a high frequency among injecting drug users with hiv/hcv coinfection and hcv mono-infection in yunnan, china. in patients with chronic hepatitis c and hiv coinfection, gbv-c rna was associated with significantly lower alt and ast levels, suggesting a beneficial effect of gbv-c infection on chronic hepatitis c. results gbv-c rna was identifie...

patients and methods five hundred and sixteen serum samples of the patients undergoing hemodialysis and kidney transplantation from various cities of khuzestan province were collected. anti-hepatitis g e2 antibodies were investigated by elisa method. rnas were extracted from serums and hepatitis g rna was detected by rt-pcr. results of the 516 samples, 38 (7.36%) specimens were positive for ant...

BACKGROUND GB virus C (GBV-C) is a flavivirus that was characterized in 1995. The prevalence of GBV-C RNA in HIV-infected subjects has not been previously studied in Iran and was therefore determined. METHODS We have investigated serum samples of 80 patients from Imam Khomeini Hospital, Tehran, Iran, whose HIV infection was confirmed in our laboratory by Western-blotting. We used nested-PCR t...

background the picture that has emerged from studies investigating hiv infected people with gbv-c viremia is that they have lower plasma hiv viral loads in comparison with hiv-positive people who did not have the gbv-c viremia. objectives since gbv-c hiv coinfection has not been studied in iran, we have designed a survey to study the outcomes of gbv-c infection on hiv infected individuals. pati...

1Tumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, United Kingdom 2Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, United Kingdom 3Department of Colorectal Surgery, John Radcliffe Hospital, Oxford, OX3 9DS, United Kingdom 4Department of Cellular Pathology, John Radcli...