نتایج جستجو برای: gatifloxacin

تعداد نتایج: 626  

2015
Wenting Ding Weiling Ni Huilian Chen Jingqun Yuan Xiaodan Huang Zheng Zhang Yao Wang Yibo Yu Ke Yao

PURPOSE To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% levofloxacin ophthalmic solution into aqueous humor after topical application. MATERIALS AND METHODS Age-related cataract patients (150 eyes in 150 cases) receiving phacoemulsification were randomly divided into three groups: a 0.3% gatifloxacin gel group (n=50), a 0.3% g...

2013
Srinivas Garaga Ambati V. Raghava Reddy Koilpillai Joseph Prabahar Raghu Babu Korupolu Paul Douglas Sanasi

Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin ...

Journal: :The Journal of antimicrobial chemotherapy 2000
J Fung-Tomc B Minassian B Kolek T Washo E Huczko D Bonner

The in vitro antibacterial spectrum of gatifloxacin was compared with those of ciprofloxacin and ofloxacin. Gatifloxacin was two- to four-fold more potent than comparator quinolones against staphylococci, streptococci, pneumococci and enterococci (gatifloxacin MIC90s, < or =1 mg/L, except 4 mg/L against methicillin-resistant Staphylococcus aureus and Enterococcus faecium). Gatifloxacin was two-...

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2006
Bhanubhai N Suhagia Shailesh A Shah Ishwarsinh S Rathod Haresh M Patel Dinesh R Shah Bhavin P Marolia

A simple and sensitive high-performance thin-layer chromatography (HPTLC) method has been developed for the quantitative estimation of gatifloxacin and ornidazole in its combined dosage forms. Gatifloxacin and ornidazole were chromatographed on silica Gel 60 F(254) TLC plate using n-butanol:methanol:ammonia (6 M) (8:1:1.5 v/v) as the mobile phase and scanned at 302 nm using a Camag TLC Scanner ...

Journal: :Antimicrobial agents and chemotherapy 1998
H Fukuda S Hori K Hiramatsu

Alternate mutations in the grlA and gyrA genes were observed through the first- to fourth-step mutants which were obtained from four Staphylococcus aureus strains by sequential selection with several fluoroquinolones. The increases in the MICs of gatifloxacin accompanying those mutational steps suggest that primary targets of gatifloxacin in the wild type and the first-, second-, and third-step...

Journal: :The Journal of the Association of Physicians of India 2006
J Kesavadev S A Rasheed

Gatifloxacin, a commonly prescribed antimicrobial can produce profound hypoglycemia and disturbances in glucose homeostasis especially in diabetes patients on sulphonylureas. Also new onset disturbances in glucose homeostasis can occur in patients who were unaffected by the previous use of gatifloxacin. Therefore it is suggested that gatifloxacin is better avoided in patients with diabetes and ...

Journal: :The Journal of antimicrobial chemotherapy 2003
K Sato H Tomioka C Sano T Shimizu K Sano K Ogasawara S Cai T Kamei

Mycobacterium tuberculosis (MTB) is capable of invading not only macrophages (Mphis) but also type II pneumocytes. In this study, we compared the antimicrobial activities of fluoroquinolones, including gatifloxacin, sitafloxacin and levofloxacin, against the MTB replication in the Mono Mac 6 human Mphi cell line (MM6-Mphis) and the A-549 human type II alveolar epithelial cell line (A-549 cells)...

2016
Seunghun Lee Jun Ho Lee Jin Hyoung Park Yeoreum Yoon Wan Kyun Chung Hungwon Tchah Myoung Joon Kim Ki Hean Kim

Moxifloxacin and gatifloxacin are fourth-generation fluoroquinolone antibiotics used in the clinic to prevent or treat ocular infections. Their pharmacokinetics in the cornea is usually measured from extracted ocular fluids or tissues, and in vivo direct measurement is difficult. In this study multiphoton microscopy (MPM), which is a 3D optical microscopic technique based on multiphoton fluores...

Journal: :Antimicrobial agents and chemotherapy 1998
I Lutsar I R Friedland L Wubbel C C McCoig H S Jafri W Ng F Ghaffar G H McCracken

The purpose of this study was to evaluate the cerebrospinal fluid (CSF) pharmacodynamics of a new fluoroquinolone, gatifloxacin (AM-1155), in experimental pneumococcal meningitis. The penetration of gatifloxacin into CSF, calculated as the percentage of the area under the concentration-time curve (AUC) in CSF over the AUC in blood, was 46 to 56%. Gatifloxacin showed linear pharmacokinetics in C...

Journal: :Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2007
Mudjalin Ovartlarnporn Wallaya Jongjaroenprasert

There have been case reports about adverse effects to glucose homeostasis related to gatifloxacin use. The authors report an elderly, non-diabetic patient who developed severe hyperglycemia after receiving oral gatifloxacin 400mg/d. He was a 73-year-old male, patient with a history of hypertension, cured vesical pheochromocytoma, idiopathic dilated cardiomyopathy, chronic renal insufficiency (b...

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