Gastroparesis is a clinical disorder characterized by upper gastrointestinal symptoms related with delayed gastric emptying of solids and liquids in the absence of mechanical obstruction. Diabetes mellitus has been the most common cause of gastroparesis and idiopathic gastroparesis also accounts for a third of all chronic cases. The most important mechanisms of gastroparesis, as understood to d...

54 OVERVIEWS OF GASTROPARESIS Gastroparesis is characterized by delayed or impaired passage of gastric contents in the absence of mechanical obstruction. Symptoms vary and include nausea, vomiting, bloating, and abdominal pain. The symptoms and clinical presentation of gastroparesis is reflective of its pathogenesis, severity, and association with predisposing or associated conditions. Gastropa...

Background/Aims Patients with gastroparesis and gastroesophageal reflux disease (GERD) often report decreased enjoyment when eating. Some patients remark that food does not smell or taste the same. To determine if taste and/or smell disturbances are present in patients with gastroparesis and/or GERD and relate these to gastrointestinal symptom severity. Methods Patients with gastroparesis and...

BACKGROUND/AIMS The prevalence of diagnosed gastroparesis is 24.2/100,000 inhabitants, but a large group of people with gastroparesis-like symptoms have never had a gastric emptying (GE) test. Some of them may have undiagnosed gastroparesis. Our aim was to estimate the prevalence of hidden gastroparesis in the community. METHODS The study was conducted in 2 parts: (1) Patients referred for a ...

Objective: We aimed to show the relationship between diabetic gastroparesis and mucosal injury by comparing the findings of upper gastrointestinal system endoscopy between patients with and without diabetic gastroparesis. Material and method: Upper gastrointestinal system endoscopy and gastric emptying scintigraphy were performed on the same day in 51 volunteer type 2 Diabetes Mellitus patients...

BACKGROUND The histopathology of the gastric mucosa in patients with gastroparesis, a condition characterized by gastric retention without obstruction, has not been described. AIM To test the hypothesis that reactive gastropathy is more common in patients with gastroparesis than in subjects with normal gastric motility. METHODS We compared the prevalence of reactive gastropathy, Helicobacte...

Article points 1. Gastroparesis associated with diabetes is a severe form of autonomic neuropathy. Symptoms include a feeling of fullness when eating, vomiting weight loss, heartburn, erratic blood glucose levels and spasms of the stomach wall. 2. Diagnosis of gastroparesis is usually made on clinical history and confirmed with gastric emptying studies and a gastroscopy. Gastroparesis is diagno...

This clinical review on the treatment of patients with gastroparesis is a consensus document developed by the American Motility Society Task Force on Gastroparesis. It is a multidisciplinary effort with input from gastroenterologists and other specialists who are involved in the care of patients with gastroparesis. To provide practical guidelines for treatment, this document covers results of p...

The ultrastructural changes in diabetic and idiopathic gastroparesis are not well studied and it is not known whether there are different defects in the two disorders. As part of the Gastroparesis Clinical Research Consortium, full thickness gastric body biopsies from 20 diabetic and 20 idiopathic gastroparetics were studied by light microscopy. Abnormalities were found in many (83%) but not al...

BACKGROUND Gastroparesis is a disorder characterized by a delay in gastric emptying of a meal in the absence of a mechanical gastric outlet obstruction. AIM To provide an evidence based overview on diagnosis and management of gastroparesis. METHODS A PubMed search was performed using search terms including gastroparesis, gastric retention, gastric emptying, accommodation, manometry, prokine...