introduction: mental stress is one of the most important causes of the gastric ulcer. on the other hand, flavonoids such as quercetin show protective effects. the aim of this study was to investigate possible protective effect of quercetin on water restraint stress-induced ulcer in rats. methods: adult male wistar rats were divided into seven groups each containing eight animals. the first grou...

The present study was performed to evaluate the anti-ulcerogenic activity of ethanol extract of Centella asiatica against ethanol-induced gastric mucosal injury in rats. Five groups of adult Sprague Dawley rats were orally pre-treated respectively with carboxymethyl cellulose (CMC) solution (ulcer control group), Omeprazole 20 mg/kg (reference group), and 100, 200 and 400 mg/kg C. asiatica leaf...

The present study was performed to evaluate the anti-ulcerogenic activity of hyaluronic acid against ethanol induced gastric mucosal injury in rats. Four groups of adult Sprague Dawley rats were orally pretreated respectively with distilled water (ulcer control groups), omeprazole (reference group), high molecular weight hyaluronic acid and 0.8% hyaluronic acid gel (experimental groups) one hou...

Jasminum sambac is used in folk medicine as the treatment of many diseases. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of J. sambac leaves against acidified ethanol-induced gastric ulcers in rats. Seven groups of rats were orally pre-treated with carboxymethylcellulose (CMC) as normal group, CMC as ulcer group, 20 mg/kg of omeprazole a...

OBJECTIVES The gastric ulcer is a common disorder of the stomach and duodenum. The basic physiopathology of a gastric ulcer results from an imbalance between some endogenous aggressive and cytoprotective factors. This study examined whether Ganoderma lucidum pharmacopuncture (GLP) would provide protection against acute gastric ulcers in rats. METHODS Sprague-Dawley rats were divided randomly ...

The present investigation was performed in aspirin and pylorus ligation-induced ulcer model in Wistar rats, in which ability of ginger oil to provide gastric protection was studied at two different doses, 0.5 and 1 g/kg po. Gastric protection was evaluated by measuring the ulcer index, serum gamma-GTP levels, total acidity of gastric juice and gastric wall mucus thickness. The results obtained ...

Indolic compounds have attracted a lot of attention due to their interesting biological properties. The present study was performed to evaluate the subacute toxicity and anti-ulcer activity of BClHC against ethanol-induced gastric ulcers. Experimental animal groups were orally pre-treated with different doses of BClHC (50, 100, 200 and 400 mg/kg) in 10% Tween 20 solution (vehicle). Blank and ul...

Malvastrum tricuspidatum is recommended in Ayurveda and Folklore Medicine for the management of gastric ulcers. Therefore, the purpose of the study was to investigate the antiulcer effect of whole plant extract of Malvastrum tricuspidatum (MTE) on ethanol (EtOH)-induced, aspirin (ASP)-induced, cold-restraint-stress (CRU) and pylorus--ligation(PL)-induced gastric ulcer models in rats. Aqueo...

Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of gastric ulcer formation have been reported to act by blocking alpha-2 adrenergic receptors, whereas drugs possessing anti-ulcer activity have ...

Herbal medicines appeared promising in prevention of many diseases. This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol. Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control was administered with 20 mg/kg omeprazole (reference drug) and 2 groups were received 250 mg/kg...