background: upper gastrointestinal (gi) bleeding remains a problem in critically ill-newborns. the use of h 2 blockers, by maintaining gastric ph ³ 4, reduces the risk of stress-ulceration and gastric hemorrhage. this study therefore, has evaluated the effects of short-term prophylactic‎ ranitidine in controlling gastric ph and prevention of gi bleeding in neonates.   methods: this randomized c...

Our previous finding of a fractal pattern for gastric pH and esophageal pH plus the statistical association of sequential pH values for up to 2 h led to our hypothesis that the fractal pattern encodes information regarding gastric acidity and that depending on the value of gastric acidity, the esophagus can signal the stomach to alter gastric acidity by influencing gastric secretion of acid or ...

Background:Upper gastrointestinal (GI) bleeding remains a problem in critically ill-newborns. The use of H2 blockers, by maintaining gastric pH ³ 4, reduces the risk of stress-ulceration and gastric hemorrhage. This study therefore, has evaluated the effects of short-term prophylactic‎ ranitidine in controlling gastric pH and prevention of GI bleeding in neonates. Methods: This randomized contr...

Background: The RightLevelpHTM indicator is a new device designed to measure pH of gastric aspirate obtained via nasogastric tube while minimizing exposure of the operator. Study Objectives: In vivo and in vitro validation of the RightLevelpHTM indicator. Methods: Patients (23) undergoing general anesthesia had placement of a nasogastric tube and gastric pH electrode catheter following endotrac...

Our previous report showed gastric mucosal surface pH was determined by alkali secretion at intragastric luminal pH 3 but by acid secretion at intragastric pH 5. Here, we question whether regulation of mucosal surface pH is due to the effect of luminal pH on net acid/base secretions of the whole stomach. Anesthetized rats with a gastric cannula were used, the stomach lumen was perfused with wea...

This placebo-controlled trial compared the effects of preoperative, intravenous cimetidine (300 mg) or ranitidine (50 mg) on gastric pH and gastric volume in 31 adult patients requiring general anesthesia. The elapsed time from drug administration to initial gastric sampling did not differ significantly between ranitidine (45 minutes), cimetidine (48 minutes), or placebo (52 minutes) treated pa...

STUDY OBJECTIVES To test the hypothesis that gastric pH would be elevated above pH 3.0 for at least 2 hours after administration of chewable, dispersible, buffered didanosine tablets. Doses tested were 200 mg (two 100-mg tablets) and 400 mg (two 200-mg tablets). We also sought to compare these doses with regard to maximum gastric pH (pHmax), time to pHmax (TpH-max), time that gastric pH exceeds...

BACKGROUND The RightLevelpH indicator is a new device designed to measure the pH of gastric aspirate obtained via a nasogastric tube while minimizing exposure of the operator. OBJECTIVE To validate the RightLevelpH indicator in vivo and in vitro. METHODS With general anesthesia, 20 patients had placement of a nasogastric tube and a gastric pH electrode catheter after endotracheal intubation...

PURPOSE To investigate gastric juice nitrate/nitrite concentration according to mucosal surface pH extent (area) of gastric corpus intimately contacting the gastric juice. MATERIALS AND METHODS We included ninety-nine patients with dyspepsia. To evaluate gastric mucosal surface pH and its extent, gastric chromosocpy was performed by spraying phenol red dye on the corpus mucosa and estimating ...