نتایج جستجو برای: gabab
تعداد نتایج: 1573 فیلتر نتایج به سال:
GABAB-receptors (GABAB-Rs) are metabotropic, G protein-coupled receptors for the neurotransmitter GABA. Their activation induces slow inhibitory control of neuronal excitability mediated by pre- and postsynaptic inhibition. Presynaptically GABAB-Rs reduce GABA glutamate release inhibiting presynaptic Ca2+ channels in both excitatory synapses while induce robust hyperpolarization K+ channels. ac...
GABAB receptors mediate slow synaptic inhibition in the nervous system. In transfected cells, functional GABAB receptors are usually only observed after coexpression of GABAB(1) and GABAB(2) subunits, which established the concept of heteromerization for G-protein-coupled receptors. In the heteromeric receptor, GABAB(1) is responsible for binding of GABA, whereas GABAB(2) is necessary for surfa...
-1 آمفتامین بصورت وابسته به دوز سبب بروز پاسخ بوییدن (sniffing) در موشهای صحرایی (rat) می شود. -2 باکلوفن، آگونیست اختصاصی گیرندهء gabab، باعث مهار رفتار بوییدن (sinffing) حاصل از آمفتامین در حیوان می شود. -3 آپومرفین بصورت وابسته به دوز سبب بروز پاسخ بوییدن (sniffing) در موشهای صحرایی می شود. -4 باکلوفن، آگونیست اختصاصی گیرندهء gabab بصورت وابسته به دوز سبب مهار رفتار بوییدن (sniffing) ناشی از...
Julia H. White Fiona H. Marshall 7TMReceptor Systems, Molecular Pharmacology Dept, GlaxoWellcome Research and Development, Medicines Research Centre, Stevenage, Hertfordshire, UK SG1 2NY. Recent advances in GABA receptor biology have resulted in elucidation of the molecular structure of a GABAB protein with similarity to metabotropic glutamate receptors (mGluRs), GABAB(1) (Ref. 1), and the subs...
Whereas most G-protein-coupled receptors (GPCRs) are monomeric in structure, y-Aminobutyric acid type B (GABAb) receptors are heterodimers of two seven transmembrane protein subunits, GABAB(i) and GABAB(2>. GABAb receptor function is dependent upon the co-expression of both these proteins which, when individually expressed, are devoid of receptor activity. Desensitisation of cell surface recept...
GABAB receptors are heterodimeric G protein-coupled receptors, which control neuronal excitability by mediating prolonged inhibition. The magnitude of GABAB receptor-mediated inhibition essentially depends on the amount of receptors in the plasma membrane. However, the factors regulating cell surface expression of GABAB receptors are poorly characterized. Cell surface GABAB receptors are consti...
GABAB receptors are the G-protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. GABAB receptors are abundant on dendritic spines, where they dampen postsynaptic excitability and inhibit Ca2+ influx through NMDA receptors when activated by spillover of GABA from neighboring GABAergic terminals. Here, we show that an excitatory signaling cascade enables spines to ...
The piriform cortex (PC), like other cortical regions, normally operates in a state of dynamic equilibrium between excitation and inhibition. Here we examined the roles played by pre- and postsynaptic GABAB receptors in maintaining this equilibrium in the PC. Using whole-cell recordings in brain slices from the anterior PC of mice, we found that synaptic activation of postsynaptic GABAB recepto...
The recently discovered GABAB receptor-positive allosteric modulators enhanced the potency and efficacy of GABAB receptor agonists in in vitro experiments. These GABAB modulators also attenuated reward and anxiety in behavioral experiments without causing the untoward side effects associated with GABAB receptor activation by agonist administration and hence exhibited potential therapeutic utili...
The effect of aging on GABAB binding was investigated in rat brain. Receptor autoradiography was used to investigate both GABAB and GABAA binding at 2 months, 3 months, 13 months, and 23 months. GABAB binding decreases significantly between 2 months and 23 months of age, as does GABAA binding, with was investigated in rat brain. Receptor autoradiography was used to investigate both GABAB and GA...
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