Palmitoylated proteins contain a 16-carbon saturated fatty acyl group that is post-translationally attached by a labile thioester bond. These modified proteins are mainly membrane-bound; the lability of the thioester bond allows the process to be reversible, a unique property of this modification. We report here that the gene for G14, located in the class III region of the human MHC, encodes a ...

The flagellated protozoan Giardia duodenalis (syn. lamblia or intestinalis) has been chosen as a model parasite to further investigate the multifunctional 14-3-3s, a family of highly conserved eukaryotic proteins involved in many cellular processes, such as cell cycle, differentiation, apoptosis, and signal transduction pathways. We confirmed the presence of a single 14-3-3 homolog gene (g14-3-...

A total of 12 diverse tomato genotypes as parents and their 32 hybrids, obtained through Line × tester mating fashion, were evaluated to observe the consequence different genetic parameters on yield contributing traits. The experiment was conducted during two consecutive years 2016-2017 2017-2018 winter seasons in a Randomized Complete Block Design (RCBD) with three replications. analysis varia...

The 14-3-3s are a family of dimeric evolutionary conserved pSer/pThr binding proteins that play a key role in multiple biological processes by interacting with a plethora of client proteins. Giardia duodenalis is a flagellated protozoan that affects millions of people worldwide causing an acute and chronic diarrheal disease. The single giardial 14-3-3 isoform (g14-3-3), unique in the 14-3-3 fam...

The flagellated protozoan Giardia duodenalis is a parasite of the upper part of the small intestine of mammals, including humans, and an interesting biological model. Giardia harbors a single 14-3-3 isoform, a multifunctional protein family, that is modified at the C terminus by polyglycylation, an unusual post-translational modification consisting of the covalent addition of one or multiple gl...

The regulation of the citrate synthase (gltA) and ATP/ADP translocase (tlc) genes of the obligate intracellular bacterium, Rickettsia prowazekii, was analyzed in rickettsia-infected respiration-deficient G14 cells. The level of the gltA mRNAII and the tlc mRNA was much lower in the total RNA isolated from the infected G14 cells grown in 1 g/l glucose (low glucose, GL) medium than in that from i...

Article history: Accepted 20 November 2013 Available online xxxx JEL classification: G12 G14

Hemoglobin Indianapolis is an abnormal human hemoglobin whose structure could not be deduced by standard techniques because of its extreme lability. This variant hemoglobin was found in two patients with the phenotype of severe jl-thalassemia. An unstable variant hemoglobin could not be demonstrated by any of the standard techniques of hemoglobin identification. Biosynthetic studies revealed an...