introduction: hemodialysis patients often develop resistance to recombinant human erythropoietin due to functional iron deficiency. in these patients iron therapy can be hazardous leading to hemosiderosis. recent studies have suggested that intravenous ascorbic acid may be able to improve this hyporeponsiveness. the aim of this study was to evaluate the effect of intravenous ascorbic acid on fu...

BACKGROUND/AIMS One of the most common causes of anemia of chronic disease (ACD) is chronic kidney disease. The main pathomechanism responsible for ACD is subclinical inflammation. The key element involved in iron metabolism is hepcidin, however, studies on new indices of iron status are in progress.The aim of the study was to assess the iron status in patients in early stages of chronic kidney...

Background: Anemia is a common problem in cancer patients. This study aimed to investigate the frequency rate of absolute and functional iron deficiency anemia among different tumors and its distribution in different stages of cancer in solid tumors. Materials and Methods: This study was performed on 597 patients with cancer referred to Ali-Ebne-Abitaleb Hospital in Zahedan. Laboratory tests in...

In this attempt to forge a useful algorithm for the management of iron deficiency, it is prudent to have a discussion of the difference between overt iron deficiency, where the body iron stores are depleted, and functional iron deficiency, also known as iron restricted erythropoiesis, where ample iron is present, but unavailable. Prior to the discovery of hepcidin, the hepatic synthesized iron ...

Iron deficiency is frequent in elderly population and is responsable for numerous clinical situations. Because of the frequent association of inflammatory diseases, chronic diseases associated with iron loss, diagnosis of iron deficiency is often difficult in elderly population. For the last ten years, new biomarkers of iron physiology lead to better understand physiology and pathophysiology of...

introduction: it is generally assumed that 50% of the cases of anemia are due to iron deficiency. the most severe consequence of iron depletion is iron deficiency anemia (ida), and it is still considered the most common nutrition deficiency worldwide. the main risk factors for ida include: inadequate iron intake, impaired absorption or transport, physiologic losses associated with chronological...