نتایج جستجو برای: friedreich

تعداد نتایج: 2912  

2011
Sven H Stüwe Oliver Goetze Larissa Arning Matthias Banasch Wolfgang E Schmidt Ludger Schöls Carsten Saft

BACKGROUND Mitochondrial dysfunction due to respiratory chain impairment is a key feature in pathogenesis of Friedreich ataxia. Friedreich ataxia affects the nervous system, heart and pancreas. METHODS We assessed hepatic mitochondrial function by (13)C-methionine-breath-test in 16 Friedreich ataxia patients and matched healthy controls. RESULTS Patients exhaled significantly smaller amount...

Journal: :Science Translational Medicine 2021

Gold quantum clusters are therapeutic in preclinical models of Friedreich ataxia.

Journal: :Physical therapy 2007
Joyce R Maring Earllaine Croarkin

Friedreich ataxia, although rare, is the most prevalent inherited ataxia. Recent insight into the disease pathogenesis is creating new hope for effective therapies. The purposes of this update are: (1) to review the etiology, presentation, and progression of Friedreich ataxia and (2) to describe a comprehensive physical therapist examination emphasizing valid and reliable performance measuremen...

Journal: :Movement disorders : official journal of the Movement Disorder Society 2012
David R Lynch Steven M Willi Robert B Wilson M Grazia Cotticelli Karlla W Brigatti Eric C Deutsch Olena Kucheruk William Shrader Patrice Rioux Guy Miller Amale Hawi Thomas Sciascia

This study tested the ability of A0001 (α-tocopheryl quinone; EPI-A0001), a potent antioxidant, to improve in vitro measures, glucose metabolism, and neurological function in Friedreich ataxia. We used an in vitro study of protection from cell toxicity followed by a double-blind, randomized, placebo-controlled trial of 2 doses of A0001 in 31 adults with Friedreich ataxia. The primary clinical t...

2012
Natalia Gabrielli José Ayté Elena Hidalgo

Background: Defects in the protein frataxin give rise to Friedreich ataxia. Results: A new Friedreich ataxia model using fission yeast has been generated, and its phenotype and proteome characterized. Conclusion: Frataxin absence triggers a complete iron starvation program, sufficient to generate all the associated respiratory defects. Significance: Our new model system may contribute to deciph...

2015
Iselin Marie Wedding Mette Kroken Sandra Pilar Henriksen Kaja Kristine Selmer Torunn Fiskerstrand Per Morten Knappskog Tone Berge Chantal ME Tallaksen

BACKGROUND Friedreich ataxia is an autosomal recessive hereditary spinocerebellar disorder, characterized by progressive limb and gait ataxia due to proprioceptive loss, often complicated by cardiomyopathy, diabetes and skeletal deformities. Friedreich ataxia is the most common hereditary ataxia, with a reported prevalence of 1:20 000 - 1:50 000 in Central Europe. Previous reports from south No...

1999
Martin B Delatycki Robert Williamson Susan M Forrest

Friedreich ataxia, an autosomal recessive neurodegenerative disease, is the most common of the inherited ataxias. The recent discovery of the gene that is mutated in this condition, FRDA, has led to rapid advances in the understanding of the pathogenesis of Friedreich ataxia. About 98% of mutant alleles have an expansion of a GAA trinucleotide repeat in intron 1 of the gene. This leads to reduc...

2013
M. Grazia Cotticelli Andrew M. Crabbe Robert B. Wilson Mikhail S. Shchepinov

Friedreich ataxia is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, dysarthria, areflexia, sensory loss, skeletal deformities, and hypertrophic cardiomyopathy. Most disease alleles have a trinucleotide repeat expansion in the first intron of the FXN gene, which decreases expression of the encoded protein frataxin....

Journal: :Journal of Neuropathology & Experimental Neurology 2015

2015
Yogesh K. Chutake Whitney N. Costello Christina C. Lam Aniruddha C. Parikh Tamara T. Hughes Michael G. Michalopulos Mark A. Pook Sanjay I. Bidichandani Annalisa Pastore

BACKGROUND Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter. This silencing mechanism is seen in patient-derived lymphoblastoid cells but it remains unknown if it is a widespread phenomenon affecting multiple cell types and tissues. METHODOLOGY / PRINCIPAL FINDINGS The humanized mouse mo...

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