collection of multiple processes that increase the chronological age of an organism leading to death is defined as aging, and even though important, it is poorly understood. recent research has shown that aging is due to biochemical and genetic changes, in interaction with environmental effects, including diet and nutrition. most knowledge on aging is based on ge­netic model system, but its mol...

objective: recent studies have shown that the use of prolonged and intermittent normobaric hyperoxia (95%) decrease the infarct volume of stroke. the aim of current study was to study the effect of an oxygen radicals-scavenger applied during intermittent normobaric hyperoxia on infarct volume in the rat brain and neurologic deficit. materials and methods: male wistar rats (250-350 g) were divi...

Background: Free radicals and reactive oxygen species(ROS) are the most important factors in formation of oxidative stress reaction. Now, radical damage has been suggested to contribute to a wide variety of diseases such as Alzheimer, atherosclerosis and cancer. Transition metal ions in the presence of the various biomolecules produce these active compounds. The aim of this study is introducing...

glucose-6-phosphate dehydrogenase (g6pd) deficient subjects are vulnerable to oxidative stress. quercetin, a flavonoids, has been employed as a potent oxygen-free radical scavenger in order to assess the protective effects of quercetin against h2o2-induced oxidative damage in g6pd-deficient and normal human erythrocytes. erythrocytes of g6pd-deficient (n = 10) and normal (n = 10) subjects were ...

reactions of free radicals and reactive oxygen species (ros) with biological molecules in vivo play an important physiological role in many diseases. 2,2-diphenyl-1-picrylhydrazyl (dpph) is a stable free radical and often used as a routine reagent to evaluate the antioxidant capacity of an antioxidant. this study was undertaken to investigate the free radical-scavenging and antioxidant activiti...

Hematoporphyrin derivative, used in photodynamic therapy of cancer, was found to generate the cysteinyl free radical as seen by spin-trapping. Oxygen appears to be an absolute requirement for thiyl radical production. Singlet oxygen may be the initiating species since azide inhibits oxygen uptake and radical production. In addition, the hydroxyl radical, or a radical with similar reactivity, is...

antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. a variety of free radical scavenging antioxidants exist within the body which many of them are derived from dietary sources like fruits, vegetables and teas. in this study the antioxidant activity and radical scavenging activity of methanolic extracts of s...

Photosynthetic oxygen reduction by isolated chloroplast lamellar systems has been studied with the aid of superoxide dismutase. Two mechanisms of oxygen reduction by illuminated chloroplast lamellar systems can be differentiated: 1. In the presence of low potential electron acceptors like AQ or MV the superoxide free radical ion is the product of autooxidation of the reduced acceptor. Addition ...

Oxygen-derived free radical formation can lead to cellular injury and death. Under normal situations, the human body has a free radical scavenger system (catalase, superoxide dismutase) that can detoxify free radicals. Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers have been used clinically to prevent the formation of oxidized LDL and to prevent reperfus...

Glyoxal is a major product of DNA oxidation in which Fenton-type oxygen free radical-forming systems are involved. To determine the mutation spectrum of glyoxal in mammalian cells and to compare the spectrum with those observed in other experimental systems, we analyzed mutations in a bacterial suppressor tRNA gene (supF) in the shuttle vector plasmid pMY189. We treated pMY189 with glyoxal and ...