This study performed a histological analysis of the effect of formocresol associated to endotoxin (LPS) in the subcutaneous connective tissue of mice. Ninety mice were randomly assigned to 3 groups (n=30). Each animal received one plastic tube implant containing endotoxin solution (10 mg/mL), formocresol (original formula) or a mixture of endotoxin and formocresol. The endotoxin and formocresol...

Most pediatric dentists in the United Kingdom and North America1,2 use formocresol pulpotomy for vital primary pulp therapy. In the United Kingdom, 54% of pediatric dentists reported concerns about possible sensitization, toxic, mutagenic or carcinogenic effects of formocresol; 42% of specialists surveyed in 2002 were considering changing their pulp technique to avoid formocresol.1 We performed...

Diluted formocresol is the most widely recommended primary tooth pulpotomy medicament, but it is not commercially available. This investigation surveyed practicing pediatric dentists about the concentration of formocresol that they use to perform pulpotomies and, if they use diluted formocresol, where they obtain it. Eight-hundred-and-six surveys were sent to a randomly selected sample of pract...

PURPOSE The purpose of this study was to compare the in-vitro effects of a European-based formocresol formulation that incorporates eugenol with formocresol alone on the adhesion of macrophages to plastic surfaces. METHODS Macrophages were obtained from Wistar rats. The adherence capacity of macrophages to a plastic surface was determined. Assays were carried out in Eppendorf tubes incubated ...

Introduction: Formocresol has been a popular pulpotomy medicament for many years. It is considered the “gold standard” in pediatric dentistry. However, concerns have been raised over its use in children. It has been reported that formocresol has toxic and mutagenic effects in cell culture, dental crypts, and precancerous epithelial cells. Therefore, additional biocompatible treatment alternativ...

INTRODUCTION Formocresol is widely used in primary teeth pulpotomies; however it is known to have several side effects. The purpose of this study was to assess pulpal changes of primary teeth pulps after pulpotomy with sodium hypochlorite and formocresol. MATERIALS AND METHODS In this randomized clinical trial, 22 teeth were selected. These teeth were randomly divided into 2 groups (formocres...

PURPOSE This investigation evaluated the success of a formocresol pulpotomy technique in which hemostasis was obtained with the same formocresol dampened cotton pellet used to medicate the root pulp stumps and to compare the findings of this investigation with data of published formocresol pulpotomy studies in which hemorrhage was controlled by traditional means. METHODS Clinical and radiogra...

Formocresol is currently the most popular agent for performing pulpotomies on primary teeth. HistOl'3gical evaluation offonnocresol-treated pu'.... tissue reveals inflammation and necrosis.4 ,5,6,8,11.1S Formocresol has been demonstrated to be toxic to connective tissue.16•18 In vitro, formaldehyde will diffuse through the apical foramen within minutes after placing formocresol in the root cana...

Formocresol applied to vital pulp tissue is absorbed systemically and distributed throughout the body. The sites of injury and the systemic effects of the intravenous administration of high doses of formocresol have been determined. The purpose of this project was to determine whether cellular injury could be detected following formocresol application to vital pulp tissue. Five dogs were anesth...

PURPOSE Formocresol and ferric sulfate were evaluated as pulpotomy medicaments using evidence-based dentistry principles. Formocresol has been challenged as a potential carcinogen and mutagen, leading to consideration of ferric sulfate. METHODS The PICOT statement was: (P) In human carious primary molars with reversible coronal pulpitis, (I) does a pulpotomy performed with ferric sulfate, (C)...